The seminar begins with a review of the detector systems which have been developed in the framework of the Medipix2 Collaboration. A brief overview of applications in industry and academic research ranging from materials analysis to medical x-ray imaging will be presented. The devices are in use in a number of applications at CERN. Atlas and CMS have specially modified detectors for measuring background radiation and in particular neutrons in real time. Similar measurements are being carried out at CERF and CNGS. At ISOLDE electron channeling experiments are taking place. At the SPS the devices are being used as active channelled beam monitors in the framework of the UA9 experiment and are being tested as high sensitivity beam loss monitors. These applications will be described in more detail. Finally ongoing and future developments will be introduced and their possible applications outlined.