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Antiprotons as probe for nuclear studies with short-lived isotopes remain unexploited despite past pioneer works at CERN/LEAR and Brookhaven. Antiprotons may represent a unique probe sensitive to the ratio of neutron and proton densities at annihilation site, i.e. at the very surface of the nucleus. In this seminar, a new project named PUMA (antiProton Unstable Matter Annihilation) is described.