Conveners
T1-7 Fluctuations and Disorder in Condensed Matter (DCMMP) | Fluctuations et désordre en matière condensée (DPMCM)
- Robert Wickham
For living cells to maintain spatial organization and functional capacity, they must deliver certain proteins to particular organelles and distribute the proteins within the organelles. This talk will focus on the physics of protein localization in mitochondria, an organelle that forms dynamic spatial networks that can span much of the cell volume. I will describe how protein translation and...
Living cells are divided into functional compartments called organelles. In eukaryotes, lipid membranes separate organelles from the cytoplasm such that each compartment maintains a distinct biochemical composition that is tailored to its function. In contrast, prokaryotes typically lack internal membranes and instead must use other mechanisms to spatially organize the cell. Using fluorescence...
Prion proteins are proteins that can fold in different structures, where one fold (the prion form) can self-propagate by converting their normally folded proteins into the prion form. In mammals, prions are the cause of untreatable neurodegenerative diseases such as Creutzfeldt-Jakob disease. Intriguingly, prion domains (often disordered sequences) are commonly found in yeast but have also...
