Jun 3 – 5, 2022
Parador El Saler, Valencia, Spain
Europe/Zurich timezone

On a way to clinical positronium imaging with the high time resolution total-body J-PET system

Jun 3, 2022, 12:15 PM
15m
Parador El Saler, Valencia, Spain

Parador El Saler, Valencia, Spain

Clinical motivation for pushing TOFPET CTR ≤ 100ps Clinical motivation for pushing TOFPET CTR resolution ≤100ps

Speaker

Pawel Moskal

Description

J-PET is a multi-photon PET system prototype [1] enabling multi-photon and positronium imaging. The quality of these images relies strongly on the system's time resolution. In this presentation, we will explain the newly developed method of positronium imaging and present the first multi-photon [2] and in-vitro positronium images [3]. We will discuss the clinical motivation for improving the system time resolution and present arguments demonstrating that the high sensitivity and high time-resolution multi-photon total-body PET systems [4] open realistic perspectives for the application of positronium as a biomarker for in-vivo assessment of the tissue pathology and the degree of hypoxia [5].

[1] P. Moskal et al., "Simulating NEMA characteristics of the modular total-body J-PET scanner - an economic total-body PET from plastic scintillators", Phys. Med. Biol. 66 (2021) 175015.

[2] P. Moskal et al., "Testing CPT symmetry in ortho-positronium decays with positronium annihilation tomography", Nature Communications 12 (2021) 5658.

[3] P. Moskal et al., "Positronium imaging with the novel multiphoton PET scanner", Science Advances 7 (2021) eabh4394.

[4] P. Moskal, E. Stepien, "Prospects and clinical perspectives of total-body PET imaging using plastic scintillators", PET Clin 15 (2020) 439-452.

[5] P. Moskal, E. Stepien, "Positronium as a biomarker of hypoxia", Bio-Algorithms and Med-Systems 17 (2021) 311–319.

Primary author

Presentation materials