Conveners
(DPMB/DCMMP) T4-1 Soft Matter and Biological Physics Symposium | Symposium sur la matière molle et la physique biologique (DPMB/DPMCM)
- Maria Kilfoil (University of Prince Edward Island / Physics)
Description
Session IV: Physical bioenergetics: Energy fluxes, budgets, and constraints in cells
Bacteria are often assumed to allocate cellular resources to maximize their exponential growth rate. This postulate, derived from studies of Escherichia coli, is commonly interpreted as an economic principle, in which the cell balances supply of and demand for “metabolic currencies” such as amino acids during steady-state growth. However, testing these predictions has been a major experimental...
Perturbation experiments—where the response of a system of interest is observed after exposure to drugs or disruptions—are commonly used to identify interactions in biochemical reaction networks. However, it is often the case that the data is only analysed for its deterministic averages, and analysis techniques also rely on specific knowledge of each perturbation’s targets. We use constraints...
Drug resistance is a global health threat that is undermining the advances of modern medicine. Non-genetic forms of drug resistance have been established over the last two decades to play an important role in drug resistance. However, the interplay between non-genetic and genetic forms of drug resistance is largely unknown, as are the evolutionary dynamics in fluctuating drug conditions.
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