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Standard Model extensions with light axions are well-motivated by the observed Dark Matter abundance and the Peccei-Quinn solution to the Strong CP Problem. In general such axions can have large flavor-violating couplings to SM fermions, which arise naturally in scenarios where the Peccei-Quinn symmetry also explains the hierarchical pattern of fermion masses and mixing. I will discuss how these couplings allow for efficient axion production from the decays of SM particles, giving the opportunity to probe axion Dark Matter in precision flavor experiments, core-collapse supernovae and the early Universe.