Speaker
Description
Animal studies remain vital for advancing radiation therapy by improving targeting precision and healthy tissue sparing. However, ethical and practical considerations necessitate alternative approaches like dosimetric phantoms. Rodent-specific phantoms enable equipment calibration, protocol verification, and standardized multicenter trials while reducing live animal use.
3D printing, particularly fused filament fabrication technology, allows accurate anatomical replication of both external and internal structures. This ensures phantoms realistically mimic biological specimens' radiation interaction properties for reliable experimental results.
In this study, we developed and evaluated a heterogenous laboratory mouse phantom using the fused filament fabrication method based on the tomographic data of the animal. The phantom's dosimetric properties were tested using 6 MeV electron beam of the clinical linear accelerator. Experimentally obtained absorbed dose by dosimetry film within the phantom, demonstrating good agreement with the planned one. This close correlation validates both the phantom's design and the experimental methodology, suggesting that 3D-printed models can reliably simulate laboratory mouse for radiation studies.
This work is supported by the RSF project No. 24-29-00642.
