Speaker
Description
CAR T-cell therapy has revolutionized cancer immunotherapy by reprogramming patient T cells to recognize and eliminate malignant cells, achieving remarkable success in hematologic cancers. However, its application to solid tumors remains challenging due to the complexity and heterogeneity of the tumor microenvironment. CARTopiaX is an advanced agent-based model developed on BioDynaMo, an open-source, high-performance platform for large-scale biological simulations that incorporates ROOT. The model enables detailed exploration of interactions between CAR T-cells and solid tumor microenvironments, supporting hypothesis testing and data-driven discovery. By combining biological accuracy with computational efficiency and scalability, CARTopiaX provides researchers with a powerful tool to investigate CAR T-cell dynamics in silico, accelerating scientific progress and reducing reliance on costly and time-consuming experimental approaches.
