15-20 June 2014
Laurentian University / Université Laurentienne
America/Toronto timezone
Welcome to the 2014 CAP Congress! / Bienvenue au congrès de l'ACP 2014!

Adaptive sorting: a new mechanism for ligand recognition

19 Jun 2014, 10:00
A-226 (Laurentian University / Université Laurentienne)


Laurentian University / Université Laurentienne

Sudbury, Ontario
Invited Speaker / Conférencier invité Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB) (R1-4) Biophysics/Soft Condensed Matter V - DMBP-DCMMP / Biophysique et matière condensée molle V - DPMB-DPMCM


Prof. Paul Francois (McGill University)


Many biological networks have to filter out useful information from a vast excess of spurious interactions. We use computational evolution to predict design features of networks processing ligand categorization. The important problem of early immune response is considered as a case-study. Rounds of evolution with different constraints uncover elaborations of the same network motif that we name "adaptive sorting". An instance of this module is present in mammalian T-cell biochemical networks. Analytical study of this motif unifies several puzzling properties of immune recognition, such as ligand antagonism and non-monotonic response time of immune response as a function of ligand concentration. It also predicts counter-intuitive loss of response at high ligand concentrations of foreign ligands for some parameter regime, which is checked experimentally.

Primary author

Prof. Paul Francois (McGill University)


Mr Jean-Benoit Lalanne (McGill University)

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