13-19 June 2015
University of Alberta
America/Edmonton timezone
Welcome to the 2015 CAP Congress! / Bienvenue au congrès de l'ACP 2015!

Investigating the correlation between molecular structure and mechanical properties of collagen using optical tweezers

17 Jun 2015, 14:30
15m
CAB 235 (University of Alberta)

CAB 235

University of Alberta

Oral (Student, Not in Competition) / Orale (Étudiant(e), pas dans la compétition) Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB) W2-11 Microfluidics and Driven Motion (DMBP) / Microfluidique et mouvement forcé (DPMB)

Speaker

Dr Marjan Shayegan (Postdoctoral Researcher)

Description

Collagens represent a prominent family of fibrous structural proteins present in the majority of connective tissues in mammals that contribute to their mechanical behaviors. Collagen self-assembles into well-defined structures including fibrils, which makes it an excellent example of a hierarchical biological system with a broad range of functions. It is known that fibril formation kinetics can be slowed down considerably by removal of short regions at both ends of collagen molecules called telopeptides. It has been suggested that telopeptides act by forming specific, transient interactions with other collagens, which could facilitate faster fibril formation. In this study, to identify and characterize interactions between collagen molecules, local viscoelastic properties of collagen systems are probed using optical tweezers.

Primary author

Dr Marjan Shayegan (Postdoctoral Researcher)

Co-authors

Prof. Nancy R. Forde (Associate Professor) Dr Tuba Altindal (Postdoctoral Researcher)

Presentation Materials

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