Conveners
T3-9 Molecular Biophysics (DMBP) / Biophysique moléculaire (DPMB)
- Maikel Rheinstadter (McMaster University)
Michael Woodside
(University of Alberta)
6/16/15, 3:45 PM
Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)
Invited Speaker / Conférencier invité
The self-assembly of intricate structures by proteins is a complex process involving myriad degrees of freedom. Such “folding” is usually described in terms of a diffusive search over a multi-dimensional energy landscape in conformational space for the lowest-energy structure. The diffusion coefficient, *D*, encodes the rates at which microscopic motions occur during folding and is thus of...
Dr
Apichart Linhananta
(Lakehead University)
6/16/15, 4:15 PM
Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)
Oral (Non-Student) / orale (non-étudiant)
Protein aggregation is a medically relevant phenomenon that can lead to protein-folding diseases such as Alzheimer’s and Prion’s. The aggregation process is largely determined by hydrogen bonds (HB), involving hundreds of peptides, over a period of days or even months. This rules out molecular dynamics (MD) simulations of all-atom protein models in explicit solvents. However, coarse-grained...
Jennifer Tang
(McMaster University)
6/16/15, 4:30 PM
Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)
Oral (Student, In Competition) / Orale (Étudiant(e), inscrit à la compétition)
Alzheimer’s disease is a type of dementia that affects memory, thinking, and behaviour. One of the hallmarks of the disease is the formation of neurotoxic senile plaques, primarily consisting of amyloid-β peptides. Despite their importance for the pathogenesis of the disease, little is known about the properties of these plaques and the process by which they form.
We developed a model...
Robert Girardin
(Lakehead University)
6/16/15, 4:45 PM
Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)
Oral (Student, In Competition) / Orale (Étudiant(e), inscrit à la compétition)
Amyloid Beta (A$\beta$) plaques have long been correlated with Alzheimer's disease; however, efforts made to link the plaques to pathogenic effects or utilize them for diagnostic purposes have not been very fruitful. Modern investigations point to peptide intermediate structures or their oligomers as likely candidates for the toxic agents, yet much remains unknown about the aggregation life...
Zhenfu Zhang
(University of Toronto)
6/16/15, 5:00 PM
Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)
Oral (Student, Not in Competition) / Orale (Étudiant(e), pas dans la compétition)
Intrinsically disordered proteins (IDPs) play critical roles in regulatory protein interactions. Cap-dependent translation initiation is regulated by the interaction of eukaryotic initiation factor 4E (eIF4E) with disordered eIF4E binding proteins (4E-BPs) in a phosphorylation dependent manner. Fluorescence correlation and time-resolved anisotropy spectroscopies were used to detect and assess...
