Electric pulses (EPs) have multiple medical applications that depend upon their impact on plasma membrane integrity and ion and molecular transport [1]; however, the motion of the ions during the EPs, which may impact the resulting phenomena, remain poorly understood. This study reports the net ion motion during the application of multiple nanosecond EPs (NSEPs) to a Jurkat cell suspension by...
Extraction of lipids from microalgae is a major barrier to the industrial production of lipid-derived biodiesel, motivating efforts to implement treatment strategies to replace or supplement solvent extraction. Pulsed electric field (PEF) treatment has shown promise in weakening the cell membrane to facilitate greater lipid yield by subsequent solvent extraction. Previous studies have assessed...
Recent research has highlighted multiple opportunities for activated platelet rich plasma (PRP)/platelet gel in wound healing [1]. This entails drawing the patient’s blood, centrifuging it to separate the PRP, and activating it by adding bovine thrombin (BT), the current state of the art clinical platelet activator, and CaCl2 to trigger platelet activation (growth factor release and clotting)....
To meet the needs of high voltage pulsed electric field for tumor therapy and tissue ablation，a design scheme of high voltage composite pulsed wave source combining classic Marx generator and all solid state switching device is proposed in this paper.Using all solid state switching devices instead of traditional spark gap switches, the unipolar Marx generator is the core of...
Irreversible electroporation (IRE) uses ~100 μs pulsed electric fields to permanently disrupt cell membranes for tumor treatment. Combining short high-voltage (SHV) pulses with long low-voltage (LLV) pulses, a new modality of the pulsed electric fields exhibits the synergistic effect which could enhance the cell cytotoxic effect. Here, the ablation by 2D monolayers mimic in vitro model and...
