10-16 June 2018
Dalhousie University
America/Halifax timezone
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Effect of cross-linking on the size-distribution of collagen fibrils (G)*

13 Jun 2018, 09:30
15m
SUB 307 (cap.80) (Dalhousie University)

SUB 307 (cap.80)

Dalhousie University

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle) Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB) W1-1 Pattern Formation and Statistical Mechanics of Non-Equilibrium Systems (DCMMP) | Formation de motif et mécanique statistique des systèmes hors d'équilibre (DPMCM)

Speaker

Samuel Cameron (Dalhousie)

Description

We have shown that collagen fibrils have a preferred equilibrium fibril radius. However, the radial distribution of fibrils in tissues is typically polydisperse. Tendon fibrils in particular can exhibit a bimodal distribution of radii within the same tissue. This suggests non-equilibrium effects are important in fibril formation. To investigate these effects, we applied 2d coarsening dynamics to a system of fibril cross sections. We adapted the dynamics to account for both the equilibrium fibril radius and age-dependent cross-linking of individual fibrils. We find for tendon fibrils that a broad range of fibril radii are stable with respect to a bulk non-fibril (cholesteric) phase, and that cross-linking freezes the fibril distribution away from the equilibrium.

Primary author

Samuel Cameron (Dalhousie)

Co-authors

Laurent Kreplak (Dalhousie) Andrew Rutenberg (Dalhousie University)

Presentation Materials

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