Conveners
6.5 Biological and Medical Applications I
- Dayun Yan (The George Washington University)
Currently, the plasma-based cancer treatment and the mechanism of plasma jet interacts with the target are hot topics. During the cell treatment, the cell feedback makes plasma jet inconsistent among different type of cells even with all other setups are the same. Therefore, such cell feedback on plasma jet cannot be neglected. In this work, we discovered how cancer cells change the plasma...
Basic research on the underlying mechanisms of pulsed electric field effects of sub-microsecond duration on mammalian cells has mostly focused on the study of individual cells in suspension. However, for cells that are organized in a tissue, connections and communication between cells are crucial. Accordingly, we investigated besides intracellular effects also extracellular effects and in...
Exposure of biological cells and tissues to magnetic fields has not been studied much, and most of the research to date has focused on electrical stimulation. However, an even newer modality that might hold promise, is based on interactions of magnetic fields with living cells and tissues. Progress in experimental techniques has resulted in the burgeoning development of new approaches to...
Typical techniques to artificially introducing nucleic acids (DNA or RNA) into cells can be divided into three categories: viral, chemical, and physical. The application space targets usually production of recombinant proteins, the study of the function and regulation of genes, the production of transgenic organisms, and as a method for gene therapy in clinical workflows. Physical means,...
Overuse of antibiotics in agriculture and healthcare has reduced the effectiveness of commonly used drugs for treating infections, motivating the development of methods to overcome antibiotic resistance to inactivate microorganisms. This study combines 300 ns electric pulses (EPs) with clinical and subclinical doses of drugs used to treat two common infectious bacteria, S. aureus and E....
Porous ceramics are used as scaffolding for tissue engineering and bone regeneration. Plasma treatment of porous calcium hydroxyapatite increases cell attachment and adhesion, improving performance as a bone substitute.[1] The mechanisms producing improvement are not well known, but surface coverage of chemisorbed O, OH and N have been correlated with increased wettability, possibly leading...
Several precursors for plasma polymerization have been studied at length, including carboxylic acids, amines, siloxanes and ethers. This is in stark contrast with amide-based precursors, for which only a limited amount of studies are available [1-5], which notably differs with the abundance of biomedical research focussing on amide-based surface modification using wet chemistry [6-8]. This...
