We propose a Grand Unifi?ed Theory of Flavour, based on SO(10) together with a non-Abelian discrete group S4, under which the unifi?ed three quark and lepton 16-plets are unifi?ed into a singlet triplet 3'. The Yukawa matrices are derived from the CSD2 flavon vacuum alignment and neutrino masses emerge from the type-I seesaaw mechanism. A full numerical ?fit is performed with 15 input parameters generating 19 presently constrained observables. We also discuss N2 leptogenesis, which ?fixes the second right-handed neutrino mass to be M2~2*10^11 GeV, in the natural range predicted by the model.
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