2-7 June 2019
Simon Fraser University
America/Vancouver timezone
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Reducing dissipation in far-from-equilibrium biomolecular processes

5 Jun 2019, 13:30
SSB 7172 (Simon Fraser University)

SSB 7172

Simon Fraser University

Oral (Non-Student) / Orale (non-étudiant(e)) Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB) W2-3 Molecular Motors (DPMB) | Moteurs moléculaires (DPMB)


David A. Sivak (Simon Fraser University)


Biomolecular machines are central actors in a myriad of major cell biological process. It seems plausible that evolution has sculpted these machines to efficiently transduce free energy (thus reducing dissipation) in their natural contexts, where stochastic fluctuations are large, nonequilibrium driving forces are strong, and biological imperatives require rapid turnover. But what are the physical limits on such nonequilibrium efficiency, and what machine designs actually achieve these limits? In this talk, I discuss a theoretical framework predicting how to rapidly and efficiently drive such noisy systems from one state to another, and describe experiments demonstrating the utility of this framework for reducing dissipation when rapidly unfolding and refolding the ‘hydrogen atom’ of biophysics, a single DNA hairpin.

Primary authors

Sara Tafoya (Biophysics Graduate Group, University of California, Berkeley) Steven J. Large (Dept. of Physics, Simon Fraser University) Shixin Liu (Rockefeller University) Carlos J. Bustamante (Dept. of Physics, University of California, Berkeley) David A. Sivak (Simon Fraser University)

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