2-7 June 2019
Simon Fraser University
America/Vancouver timezone
Welcome to the 2019 CAP Congress Program website! / Bienvenue au siteweb du programme du Congrès de l'ACP 2019 !

Design and synthesis of an artificial molecular motor: The Lawnmower

Jun 5, 2019, 2:00 PM
15m
SSB 7172 (Simon Fraser University)

SSB 7172

Simon Fraser University

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle) Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB) W2-3 Molecular Motors (DPMB) | Moteurs moléculaires (DPMB)

Speaker

Chapin Korosec (Simon Fraser Univ)

Description

Despite the second law of thermodynamics and a harsh thermal environment, molecular motors, among their many talents, are capable of directed motion and long range transport within cells. In this talk I will discuss our approach towards understanding how directed and processive motion is achieved at the molecular scale through the synthesis of an artificial molecular motor comprised of no biological motor components. Our system is designed to achieve directed motion through a burnt-bridges ratchet mechanism whereby it cleaves peptide substrate sites as it moves, thereby inhibiting backwards stepping. The substrate sites are presented to the motor as a ‘lawn’ through the tips of a dense polymer brush; we therefore call our artificial motor ‘the Lawnmower’. I will present our preliminary experimental results of the micron-sized lawnmower on a two-dimensional lawn, as well as present our kinetic Monte Carlo simulations which offer design principles for a nano-scaled version [C.S. Korosec et al., Phys. Rev. E, 98(3), 2018].

Primary author

Chapin Korosec (Simon Fraser Univ)

Co-authors

Dr Martin J. Zuckermann (Department of Physics and Department of Molecular Biology and Biochemistry, Simon Fraser University, Canada) Mr Michael W.H. Kirkness (Department of Molecular Biology and Biochemistry, Simon Fraser University, Canada.) Nancy Forde (Simon Fraser University)

Presentation materials

There are no materials yet.