2-7 June 2019
Simon Fraser University
America/Vancouver timezone
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Non-equilibrium response of a strongly coupled rotary motor

Jun 4, 2019, 12:00 PM
ASB 10900 (Simon Fraser University)

ASB 10900

Simon Fraser University

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle) Symposia Day - Soft Matter Canada 2019 T2-1 Soft Matter AM-2 (DCMMP) | Matière molle AM-2 (DPMCM)


Ms Emma Lathouwers (Simon Fraser University)


Living systems at the molecular scale are complex (composed of many constituents with strong and heterogeneous interactions), far from equilibrium, and subject to strong fluctuations. Energy conversion in such contexts would seem to be challenging, yet nature has evolved numerous molecular machines that efficiently, precisely, and rapidly transduce free energy between non-equilibrium reservoirs. Here we discuss design principles for effective free energy transduction in a simple model of FoF1 ATP synthase, a rotary motor that is crucial for virtually all living things. In particular, we discuss the interplay between non-equilibrium driving forces, natural equilibrium fluctuations, and interactions between the strongly coupled sub-systems that comprise the full machine.

Primary authors

Ms Emma Lathouwers (Simon Fraser University) Mr Joseph Lucero (Simon Fraser University) David Sivak (Simon Fraser University)

Presentation materials