Conveners
Methods for production of novel radioisotopes for theranostics
- CATHY CUTLER (Brookhaven National Laboratory)
- Ulli Koester (Institut Laue-Langevin (FR))
Radionuclides are used in different fields of medicine like oncology, neurology and cardiology, either for diagnostic or therapy. In most cases, radionuclides must be coupled to a carrier molecule to target the cells of interest. Many radionuclides may be of medical interest due to their emitted radiations (beta / alpha emitters, Auger emitters) and/or their half-lives that can be adapted to...
Much like at ISOLDE, the unused primary beam at the Facility for Rare Isotope Beams (FRIB) will retain a majority of its isotope-producing capability even after passing through the main target. In the spirit of MEDICIS, we are planning to make use of that unused capacity to access valuable radioisotopes for applications such as theranostics. This secondary isotope production will occur mainly...
Terbium is an element having four radioactive isotope of interest for nuclear medicine: Tb-149 and Tb-161 for therapy and Tb-152 and Tb-155 for imagery. The production of Tb-161 isotope can be done efficiently with high specific activity in nuclear reactor using Gd-161 target, the isotopes of Tb-149, Tb-152 and Tb-155 can be produced in a commercial cyclotron using a proton beam with energies...
ISOLPHARM [1] (ISOL technique for radioPHARMaceuticals) is a project devoted to the discovery and development of high specific activity radiopharmaceuticals exploiting radionuclides producible with the future SPES (Selective Production of Exotic Species) ISOL (Isotope Separation On-Line) facility at INFN-LNL.
The strength point of such production method is the capability to produce a wide set...
Radioisotopes of terbium (149, 152, 155, 161Tb) have been identified as a potential theranostic quartet for use in nuclear medicine. Any such radiopharmaceutical based on the radioisotopes would be required to have a low (< 0.1 %) level of radionuclidic impurities, therefore it is crucial that chemical separation techniques are developed to ensure these thresholds are met while maintaining a...
Er-169 (half-life 9.39 d) is an almost pure β- emitter characterized by low energy electrons emission and few low energy and very low intensity gamma rays. It is currently produced in nuclear reactors through the neutron activation of Er-168, which is one of the 6 natural erbium isotopes. Er-168 is commercially available at around 98% enrichment level; nevertheless, the cross section of the...
Abstract: Aerodynamic isotope separation in a free gas jet is enhanced by 2 orders of magnitude by laser-induced isotopically selective condensation. The method is quite generally applicable and is demonstrated for separating S, Br and Si isotopes. The separation of Mo isotopes is discussed in detail for the production of 100Mo for the 100Mo(p,2n)99Mo reaction and the production of 99mTc for...
The chemical vapour deposition (CVD) of graphene is the most promising route for the production of large-area graphene films. In this work, the growth of graphene on transition metals via CVD was investigated. The mechanisms of graphene formation on metals with different carbon solubility and therefore different affinity to carbon were observed and discussed.
In this work, three transition...
