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Background: Radioactive ion beams at ISOLDE are produced by the interaction between an intense proton beam with a thick target material [1]. Micrometric UCx-based targets are the current reference at ISOLDE, but a significant increase on the yields of exotic isotopes is expected to be obtained from nanostructured and porous UCx targets.
Key Method: Electrospinning is a top-down...
Our developments on production of 165Er and 52Mn [1] for bimodal sensor MRI/PET or SPECT turn to be necessary an automatisation of separation process especially in case of 52Mn in terms of radiation protection. For that, a homemade system has been developed for purification of radiometal target especially for separation step with homemade software, ACCRA to remote control all operations. The...
ISOLPHARM-Ag is a branch of the SPES project (Selective Production of Exotic Species) aimed at the production of carrier free 111Ag for nuclear medicine application at INFN-LNL (Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali di Legnaro). [1, 2]
Among all the radionuclides that will be produced by the future ISOL facility (Isotope Separation On Line), 111Ag is regarded as a very...
Folate-based radiopharmaceuticals were applied for targeting the folate receptor (FR) positive malignant tissue while cyclic Arg-Gly-Asp (c(RGD)) peptides were used to target αvβ3 integrin which is overexpressed during tumor angiogenesis. Combination of these two different targeting motifs in one molecule could be utilizable for dual-targeting. Here, we present the introduction of folate and...
Our goal is to contribute for the development of new strategies for prostate cancer theranostics, based on bombesin (BBN) analogues with very high affinity and specificity for the GRP receptor (GRPr) and on a multistep pretargeting strategy. To achieve this goal, we have opted by in vivo inverse-electron demand Diels-Alder (IEDDA) reactions between BBN antagonists carrying a trans-cyclooctene...
Gold nanoparticles (AuNPs) can play a pivotal role in the design of new theranostic tools for cancer treatment. This is due to their appealing properties for medical application such as, biocompatibility, easy functionalization with molecular vectors and good biological half-life. Additionally, AuNPs can also be explored as multifunctional platforms for targeted-delivery of radionuclides and...
Over the last few years, several studies have proven the effect of targeted alpha therapy using Ac-225 and Bi-213 [1, 2, 3]. One of the crucial bottlenecks in upscaling these studies and moving to clinical trials is the availability of these isotopes. The current production methods cannot provide sufficient quantities of Ac-225 or its daughter Bi-213. Furthermore, some of these production...
Four terbium isotopes (149Tb, 152Tb, 155Tb, and 161Tb) have been shown to possess physical and chemical properties suitable for all therapeutic and diagnostic applications in nuclear medicine[1]. If a diagnostic (e.g. 155Tb) and therapeutic (e.g. 161Tb) terbium isotope can be combined, then it would give theranostic pair with identical chemical properties. This is a particularly promising...
Radioisotopes are one of the essential cornerstones of modern medicine. They may be used for both diagnostic and therapeutic purposes. Here we present full describtion of a 12 MeV compact high field superconducting cyclotron with a magnetic field 2 times higher than conventional H- cyclotrons that has been developed recently. This cyclotron will be a modern, state of the art design, which,...
In a context of development of radiometals (165Er, 52Mn or 89Zr) for imaging applications at Orleans’ cyclotron, more regular and higher activities are necessary. For that, a new targetry was developed for solid target using a known cooling system [1] where target was in a shuttle. In this targetry, two measurements of temperature have been integrated: one by thermocouple on the backside of...
The medical use of radioactive isotopes for diagnosis and treatment is a publicly accepted and well supported success history. The rapid growth of molecular imaging, PET scanning and radionuclide therapy of cancer has increased the demand for isotope production across the globe. Unfortunately, we are also witnessing the decreased availability of large nuclear facilities due to aging facilities...
