It is well known that the DIS and Drell-Yan processes are two key experimental approaches to reveal the partonic structure of nucleons via either the space-like or time-like virtual photons. Conventionally the nucleon GPDs are explored by DVCS and DVMP processes using lepton beam. In this talk I will introduce a complementary measurement of nucleon GPDs by the exclusive pion-induced Drell-Yan process $\pi^- p \to \gamma^* n \to \mu^+\mu^- n$. A feasibility study using E50 high-resolution spectrometer in the coming high-momentum beam line of Hadron Hall at J-PARC has been carried out [PRD 93, 114034]. A clean signal of exclusive Drell-Yan process can be identified in the missing-mass spectrum of triggered dimuon events. Realization of such measurement at J-PARC will open up a new way of accessing nucleon GPDs as well as provide the fundamental test of the universality of GPDs.