May 24 – 28, 2021
America/Vancouver timezone

TOPAS Simulations for Estimating 48V Yields of Natural Titanium Foil Irradiation

May 27, 2021, 5:00 AM
Poster Technology Transfer Tech Transfer Posters


Brittany Broder (University of Chicago)


Natural titanium foils can be used in the production of several medical isotopes, including β+ emitter vanadium-48. Due to its 16 day half-life, vanadium-48 has potential application in long-term monitoring and longitudinal studies. While foils are often irradiated via solid target system, medical cyclotrons lacking these systems often have components that can be manipulated for this purpose, such as placing thin foils in a beamstop. In this work, we simulate the irradiation of natural titanium foils via TOPAS, a Geant4-based Monte Carlo program, calculate the theoretical yield using cross section data from the literature, and compare the results to the experimental yield of 12 µm foils bombarded in a beamstop with 18 MeV protons via compact medical cyclotron IBA 18/9 Cyclone. TOPAS results produced a 10% difference compared to experimental results and a 54% difference compared to theoretical calculations, indicating that factors such as foil angle may have lowered experimental yields.

Funding information Graduate Fellowship in STEM Diversity, NIH Cancer Center Support Grant (#P30 CA14599) to the University of Chicago Comprehensive Cancer Center
TIPP2020 abstract resubmission? No, this is an entirely new submission.

Primary author

Brittany Broder (University of Chicago)


Richard Freifelder (University of Chicago) Mohammed Bhuiyan (University of Chicago) Anna Kucharski (University of Chicago) Chin-Tu Chen (University of Chicago)

Presentation materials