Conveners
M3-3 MR and PET Imaging - Part 1 (DPMB) / Imagerie RM et TEP - Partie 1 (DPMB)
- Emily Heath
Temporal diffusion spectroscopy (TDS) has been used to infer axon sizes using geometric models that assume axons are cylinders. A celery sample was imaged to test if the importance of other geometric models. The vascular bundles and collenchyma tissue (~20 μm cells) in celery can be modeled as containing cylindrical cells. Whereas the parenchyma cells are rounder and are 3-4 times larger in...
Positron Emission Tomography (PET) images of the brain can reflect the level of brain molecular metabolism with low spatial resolution, while magnetic resonance imaging (MRI) brain images can provide anatomical structure information with high spatial resolution. In order to achieve the complementary of molecular metabolism information and spatial texture structure, it is meaningful to fuse the...
Tissue microstructure, such as axon diameters, can be inferred from MRI diffusion measurements either through relating models of the geometry of the tissue and MR parameters, or through directly relating MR measurements to tissue parameters. Some have implemented geometric models to infer axon diameters using temporal diffusion spectroscopy. In order to target smaller diameter axons, we have...
Magnetic Resonance Imaging (MRI) detects signal from hydrogen nuclei in biological tissue. MRI requires a homogeneous static magnetic field to generate artifact-free images. The subject is spatially encoded with magnetic field gradients. The signal is acquired in the frequency domain and the image is reconstructed by inverse Fourier transform. Objects with high magnetic susceptibility, such as...
Introduction: pHi is a hallmark of altered cellular function in the tumour microenvironment and its response to therapies. One of the main acid-extruding membrane transport proteins in cells is the Na+/H+ exchanger isoform 1 (NHE1). Chemical exchange saturation transfer (CEST) MRI uniquely images pHi. In CEST-MRI, contrast is produced by exciting exchangeable tissue protons at their...
**Introduction:** MRI’s low sensitivity, caused by the use of nuclei with low-gyromagnetic ratios or low magnetic field strength, can presently be improved with expensive high-field MRI-hardware and/or expensive enriched-isotopes. We propose a new method that does not require any extra signal-averaging or hardware to improve the quality of MRI images. We will use a significant k-space...
Magnetic resonance imaging (MRI) is widely used as a non-invasive diagnostic technique to visualize the internal structure of biological systems. MRI has limited spatial resolution and the microscopic behaviour within an image voxel cannot be visualized with qualitative images. Quantitative analysis of molecular diffusion provides insights into the microscopic structure beyond the MRI image...
