Speaker
Description
Biological tissues generate active mechanical stress, originating from cellular force dipoles. Active fluid theory predicts this active stress to drive a spontaneous flow transition in a confined geometry.
Indeed, polar cells on a confining disc are observed to rotate with spiral orientation. However at a later stage, tissue growth induces cell reorientation into a static aster.
To explain this transition, we introduce a passive theoretical coupling between cell density and polarity. Such coupling can lead to patterning effects, allowing spiral-aster coexistence on a disc.
This work shows that cell density gradients can compete with activity to stabilize out-of-equilibrium spatial structures that may be relevant to tissue morphogenetic events.
| Theoretical Work | Theory |
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