Speaker
Description
Mitochondria are heterogeneous organelles best known for their role in energy production through oxidative phosphorylation. Yet, they possess their own genetic material, encoding for key ox-phos proteins. Thus, they must divide to proliferate, which they do asynchronously from their host cell cycle. How do they ensure network maintenance and homeostasis? Using a customized structured illumination microscope, we discovered patterns underlying their division and genome organization, linked to biogenesis and quality control. We share new findings on the interplay between these processes and organelle trafficking within the cell. The intermittent dynamics of these processes imply that a constant imaging speed may miss important features. Thus, we also developed event-driven acquisitions, an adaptive microscope control that uses neural networks to enrich datasets for events of interest.