Speaker
Friso Douma
(EPFL)
Description
Having the correct number of centrioles is crucial for the cell and this is ensured by duplicating centrioles strictly once every cell cycle. While three important proteins have been identified, the mechanism by which these provide incredibly robust control of organelle copy number remains unknown. I will discuss Turing-based theoretical approaches to understand how self-organization and patterning control centriole assembly. To constrain models with experimental data, I will show how interdependencies of the three key proteins are revealed using super-resolution microscopy. Together, these approaches provide key insights in centriole duplication and demonstrate how self-assembly can be precisely controlled in biology.
Authors
Friso Douma
(EPFL)
Prof.
Pierre Gönczy
(EPFL)
