NRC-8, EuCheMS International Conference on Nuclear and Radiochemistry

INVITED LECTURE - Labeling of radiopharmaceuticals with Iodine-124 and their clinical applications

17 Sept 2012, 14:40

20m

Como, Italy

Invited Lecture Radiopharmaceutical chemistry, radiodiagnostics, radiotherapy, theragnostics Session 2 (cn't of Session 1) - Radiopharmaceutical Chemistry (radiodiagnostics, radiotherapy, theragnostics)

Speaker

Dr Naga Vara Kishore Pillarsetty (Memorial Sloan-Kettering Cancer Center, USA)

Description

Iodine isotopes (I-123, I-125 & I-131) have greatly contributed toward expanding the applications of isotopes in medicine; these applications range from ex vivo radioimmuno assays to in vivo SPECT imaging. Iodine-124 (t1/2 = 4.2 d; b+ 23%) was long considered an impurity in iodine-123 production, has lately seen a renaissance in its applications as a PET isotope in clinics due to the ability to produce usable quantities on small hospital-based cyclotrons. This presentation will present an overview of current approaches for production and isolation of iodine-124 and methods for incorporation of iodine-124 onto small molecules, peptides and antibodies. Direct labeling and indirect labeling methods for radioiodination of biological molecules will be discussed in detail. The later part of the talk will exemplify the impact of Iodine-124 based PET radiopharmaceuticals in the clinical setting. Specific examples of pre-clinical and clinical applications including [124I]-NaI for measuring MAPK inhibition and sensitization to radioiodine therapy, [124I]-PU-H71 - a small molecule inhibitor of Hsp90 for measuring drug pharmacokinetics and predicting response to therapy and [124I]-G250-a radioiodinated antibody against CAIX antigen for detecting renal cell carcinoma will be presented.