OnlineLectures

ASP Online Seminars: Lipid deregulation as a biomarker to prevent retinal degeneration

by Dr Christelle Ekosso (University of North Carolina at Chapel Hill)

GMT
Description

Abstract:

The autosomal dominant Retinitis Pigmentosa (RP) is a neurodegenerative disease commonly caused by the misfolding opsins that aggregate in the endoplasmic reticulum (ER) during the mutation of Proline-to-Histidine substitution in cordon 23 (P23H).

 The aggregation due to the increase of beta-sheet deregulates the chemical composition of retinal layers. To provide a better understanding and therapeutic issues of the disease, Fourier Transform Infrared Spectroscopy Imaging (FTIR) was used to study and quantify the chemical composition of mice retinal layers (wild type and mutant samples).

The results obtained from statistical data analysis by comparing both groups (wild type and mutant samples) suggest that the misfolding opsins (P23H) in the photoreceptor layer disrupt the chemical composition (both protein and lipid composition) of retinal layers especially the outer nuclear and the outer plexiform layers.

In fact, by comparing the wild-type and mutant samples, we found that the lipid composition is significantly deregulated in mutant samples. This deregulation affects the transmission process in the retina.

 

 

Organized by

IOC
Dr. Christelle Ekosso (ASP2016 Alumna)

Videoconference
Zoom Meeting ID
92372698210
Host
Ketevi Adikle Assamagan
Alternative host
Steve Muanza
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Participants
Participants
  • Abdurrazaq Abdulgaffar
  • Behzad Salmassian
  • Bintou Bamba
  • Christelle Ekosso
  • clemence Simo
  • ebode onyie fabien
  • FOBASSO MBOGNOU FLORETTE CORINNE
  • Jean Baptiste Fankam Fankam
  • Kayode DADA
  • Ketevi Adikle Assamagan
  • Mounia Laassiri
  • Oumar Ka