The MEG II experiment searches for rare muon decays at PSI, Switzerland. One of the challenges of this experiment is to measure timing of calorimeter and timing counters with a precision down to a few pico seconds. This is accomplished by using the DRS4 Switched Capacitor Array and a high precision timing system using a custom crate standard synchronizing more than 30 crates with over 9000 channels.
We will report the dos and don'ts in designing and running such a large system over several years. This includes clock generation and fan-out, jitter cleaning, noise effects and global time calibrations. The gained experience will be presented in a way that it will be well applicable to other experiments seeking for the ultimate timing.