Four fatigue test procedures were used in the present study in order to investigate the fatigue behaviour of OFE copper: conventional fatigue (CVF), ultrasonic swinger (USS), laser fatigue (LAF) and radio-frequency fatigue (RFF). Characterisation and quantification of roughening and hardening phenomena on cycled samples revealed a strong dependence on the orientation of individual grains of the polycrystalline material. Additionally, grain boundaries need to be considered in fine structures (grain sizes as fine as 1 µm - 5 µm). The results obtained in the present study provide a framework for discussing material selection and material pretreatments, developing alternative engineering designs and working out monitoring strategies for long-term operation of the CLIC-AS.