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Abstract: The Modane Underground Laboratory (LSM) is the deepest tunnel-access underground laboratory in Europe. The experimental site is protected by a 4800 m.w.e. overburden that reduce the muon flux to 5 muons/m2/day, and is thus ideal for a wide range of applications requiring ultra-low radioactivity levels. I will present the evolution of this facility and of its science program in the domain of dark matter, neutrinoless double-beta decay and interdisciplinary sciences. A special focus will be dedicated to the future TESSERACT experiment for low-mass dark matter searches. The possibility to host it at the LSM and the French-based cryogenic semiconducting (Ge, Si) detector technology will be detailed.