We give a brief overview of the Vcb-puzzle, a mismatch of extractions of the CKM-element V_cb from inclusive and exclusive B-decays, and its importance for precision flavor physics. Complementary extraction is possible from W-decays at the LHC. We report on the recent determination of Vcb from ttbar at CMS, https://cds.cern.ch/record/2972245, and discuss prospects.