There are several observables in processes with heavy quarks that appear to be anomalously large experimentally: the forward-backward asymmetry in ttbar production (A_FB), the direct CP asymmetry in two body D decays (Delta A_CP) and the probes of lepton universality in semileptonic B decays. I will give an overview of these processes, both the present experimental status as well as standard model and new physics interpretations. For instance, there are tight constraints on NP models that could explain A_FB. Many NP models that were on the market before the first top results from the LHC are now in tension with the charge asymmetry measurements at the LHC. For general enough new physics models the correlation between the two observables is lost, however. On the other hand, there is some support for the SM origin of Delta A_CP. Reasonable NP models can also explain Delta A_CP and one can distinguish between the two of them experimentally using just charm decay data. Finally, I will show that at least in the effective field theory a consistent picture of lepton universality violation recently hinted at by BaBar is possible and what types of models could explain it.