OpenLoops is an automatic and fully flexible generator of one-loop scattering amplitudes. It is based on a new algorithmic concept introduced in arXiv:1111.5206 [hep-ph], which permits to compute one-loop corrections to multi-particle Standard Model processes in a highly efficient and numerically stable way. After a presentation of the OpenLoops algorithm, in this talk I will illustrate its technical performance and demonstrate the possibility to compute hadronic NLO cross sections in a fully automatised way using OpenLoops and Sherpa.