In this talk I will give an update on analysis of several large data sets from the LHC experiments as well as applications in smaller R&D applications. I will give an update
on its application in the latest versions of ROOT and Mathematica (release 9) and illustrate
the potential role of new technologies in Mathematica and Alpha to high energy physics computing. There have been several discussions at CERN and elsewhere about the potential benefit to our community of further collaboration with Wolfram. I will also touch on these in my talk.