The LHC sensitivity to an anomalous Higgs coupling to the top quark in the Higgs-top associated production is analyzed. Thanks to the strong destructive interference in the t-channel for standard model couplings, this process can be very sensitive to both the magnitude and the sign of a nonstandard top-Higgs coupling. We analyze cross sections and the main irreducible backgrounds for the H -> gamma gamma decay channel. Sensitivities to an anomalous sign for the top Yukawa coupling are found to be large.