Searches for supersymmetry usually assume a flavor-blind superpartner spectrum. In particular, the first- and second-generation squarks (sleptons) are assumed to be degenerate with no inter-generation mixing. As I'll explain, both theory considerations and low-energy experimental constraints allow for non-degenerate sfermions and/or flavor mixing, with potentially significant effects on LHC searches. I'll comment on both squark production and slepton production, but my main focus will be on simplified models for EWK/slepton searches.