Speakers
Dr
Andrea Perrotta
(Dip. Fisica e INFN, Bologna)Prof.
Francesco Navarria
(Dip. Fisica e INFN, Bologna)
Description
The aim of the SCINTIRAD experiment is to determine the radio-response to 188Re in various cells in vitro,
the biodistribution of the radiopharmaceutical in different organs of mice in vivo, and subsequently the
therapeutic effect on liver tumours induced in mice inoculated with M5076 murine fibrosarcoma cells.
Both the gamma and beta emissions of 188Re have been used in the experiment. The in-vivo biodistribution
in mice is studied with a gamma camera using different parallel hole collimators. In the 188Re spectrum, while
the 155 keV gamma peak is useful for imaging, less intense photon lines emitted at larger energies (given
their much larger penetration) and the beta particles emitted in the decay (given the secondary interactions
they can generate everywhere in the FOV) act as noise from the point of view of the image reconstruction.
Gamma cameras previously used to image biodistributions obtained with 99Tc are therefore not optimized for
use with 188Re. A new setup of the gamma camera has been studied for 188Re: 66x66 YAP:Ce crystals
(0.6x0.6 mm2, 5μm optical insulation between crystals, thickness 10 mm) guarantee a FOV of 40x40 mm2; a
Hamamatsu R2486 PSPMT, 3 inch diameter, converts their light output into an electrical signal and allows
reconstructing the spatial coordinates of the light spot; the direction of the incoming photon is selected by a
Lead collimator with 1.5 mm diameter parallel hexagonal holes, 0.18 mm septa, and 40 mm thickness.
Using the new setup, preliminary results have been obtained both with 99Tc filled capillaries and 188Re filled
capillaries and small phantoms. The energy spectrum of the collected photons and some preliminary
measurement of the spatial resolutions achievable with the two sources will be presented. In addition the first
experiment of imaging with a mouse in vivo is planned well ahead the beginning of the conference and will be
reported.
The preliminary results obtained so far suggest that radiopharmaceuticals containing 188Re and HA may
represent useful tools for the treatment and imaging of liver tumours.
Supported by INFN, Gruppo V.
Author
Dr
Antonio Antoccia
(INFN, Dipartimento di Biologia,University Roma Tre)
Co-authors
Dr
Alessandra Banzato
(Dip. Sc. Oncologiche e Chirurgiche, Padova)
Dr
Andrea Perrotta
(Dip. Fisica e INFN, Bologna)
Dr
Anna Nadali
(Dip. Scienze Farmaceutiche, Padova)
Dr
Antonella Sgura
(INFN,Dip. Biologia,“Roma Tre)
Dr
Antonio Rosato
(Dip. Sc. Oncologiche e Chirurgiche, Padova)
Prof.
Caterina Tanzarella
(INFN,Dip. Biologia,“Roma Tre)
Prof.
Dante Bollini
(Dip. Fisica e INFN, Bologna)
Dr
Davide Camporese
(Dip. Scienze Farmaceutiche, Padova)
Prof.
Francesco De Notaristefani
(Dip. di Ingegneria Elettronica di Roma 3, INFN.)
Prof.
Francesco Navarria
(Dip. Fisica e INFN, Bologna)
Prof.
Giuliano Moschini
(INFN, LNL, Padova;)
Dr
Giuseppe Baldazzi
(Dip. Fisica e INFN, Bologna)
Dr
Laura Melendez
(Dip. Scienze Farmaceutiche, Padova)
Dr
Mattia Riondato
(Dip. Scienze Farmaceutiche, Padova)
Mr
Michele Bello
(INFN, LNL, Padova;)
Prof.
Nikolay Uzunov
(INFN,LNL, Padova)
Prof.
Ulderico Mazzi
(Dip. Scienze Farmaceutiche, Padova)
