Speaker
Dr
George Loudos
(Biomedical Simulation and Imaging Application Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens)
Description
A mouse sized camera has been built in terms of a collaboration between the
presenting insitutions. The system will be used for the performance of dynamic
studies in small animals, in order to evaluate novel radiopharmaceuticals. The
active area of the detector is approximately 48 mm x 96 mm allowing depiction of the
entire mouse in a single view. The system is based on two flat-panel Hamamatsu H8500
position sensitive photomultiplier tubes (PSPMT), a pixellated NaI(Tl) scintillator
and a copper-beryllium (CuBe) parallel-hole collimator. In this work the evaluation
results of the system are presented, using phantoms and small animals injected with
conventional radiophrmaceuticals. Average resolution was ~1.6mm on the collimator
surface and increased to ~4.1mm in 12cm distance from the detector. The energy
resolution was measured and found ~15.6% for Tc99m. Capillary imaging demonstrated
system's high resolution and sensitivity in activity variations. Initial dynamic
studies have been carried out in small animals injected with Tc99m-DTPA and Tc99m-
MDP. Successive images were acquired. Counts in ROIs were plotted as a function of
time. The results show systems ability to perform kinetic imaging in small animals.
Currently dynamic studies are carried out in mice and rats injected with Tc99m-
Bombesin derivatives and results will be presented as well. As a next step system's
performance will be tested using two pinhole collimators and initial tomographic
studies will be carried out using a rotating table and phantoms. Future upgrading of
the system to an integrated SPECT/CT is planned.
Author
Dr
George Loudos
(Biomedical Simulation and Imaging Application Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens)
Co-authors
Dr
Alexandra Varvarigou
(Institute of Radioisotopes-Radiodiagnostic Products, National Center for Scientific Research "Demokritos", 153 10, Athens, Greece)
Dr
Andrew Weisenberger
(Thomas Jefferson National Accelerator Facility, Newport News, VA, 23606, US)
Prof.
Konstantina Nikita
(Biomedical Simulation and Imaging Application Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens)
Mr
Nicolas Sakellios
(Biomedical Simulation and Imaging Application Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens)
Prof.
Nikolaos Uzunoglu
(School of Electrical and Computer Engineering, National Technical University of Athens)
Dr
Penelope Bouziotis
(Institute of Radioisotopes-Radiodiagnostic Products, National Center for Scientific Research "Demokritos", 153 10, Athens, Greece)
Dr
Randy Wojcik
(Thomas Jefferson National Accelerator Facility, Newport News, VA, 23606, US)
Dr
Stan Majewski
(Thomas Jefferson National Accelerator Facility, Newport News, VA, 23606, US)
