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Prof. David Townsend (University of Tennessee Graduate School of Medicine)12/05/2006, 08:30S9_S10 Molecular ImagingoralFrom autoradiography to planar X-rays, Computed Tomography (CT) and Magnetic Resonance (MR), morphology and structure has been the mainstay of biological and medical imaging for over a century. While structural changes may suggest the presence of disease, functional changes are more sensitive indicators of early- stage pathology, and where cancer is concerned, early detection is the...Go to contribution page
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Dr Keiko Imamura (Department of Radiology, St. Marianna University School of Medicine)12/05/2006, 09:00S9_S10 Molecular ImagingoralRegarding that new molecular imaging technologies mostly emerge from isotopic imaging, it is important to reevaluate preceding technologies of other modalities and their current role in clinical medicine in order to understand what we presently know and what are needed. Among many modalities, MR spectroscopy (MRS) should be reemphasized because it is a robust in-vivo technique which...Go to contribution page
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Dr Hafid BELHADJ-TAHAR (Groupe Santé Recherche)12/05/2006, 09:15S9_S10 Molecular ImagingoralIntroduction Cancer constitutes one of the first causes of mortality in the world. This proliferative disease is characterised by two evolutionary components made of regional extension and metastatic diffusion. The therapeutic success of cancer treatment depends on precocity of the diagnosis, of extension assessment and initial treatment of primitive tumour and its metastatic...Go to contribution page
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Prof. John Mertens (BEFY, Vrije Universiteit Brussel)12/05/2006, 09:30S9_S10 Molecular ImagingoralThe Na+-independent L-type LAT amino acid transport system 1 for neutral and lipophilic amino acids has been shown to be increased in tumour tissue relative to normal tissue, and the LAT system has been regarded as a key-point for the development of new amino acid based tumour tracers for molecular imaging. We have proven in vitro and in vivo that the new compound 2-I-L-phenylalanine...Go to contribution page
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Ms Ya-Fang Chang (Institute of Radiological Sciences, National Yang-Ming University, Taipei, Taiwan)12/05/2006, 09:45S9_S10 Molecular ImagingoralRecently, molecular imaging of reporter gene expression provides a rapid, sensitive, and noninvasive monitoring of tumor behaviors. In this study, we reported the establishment of novel animal models using immunodeficient mice for longitudinal examination of tumor growth kinetics and metastatic spreading in vivo. The highly metastatic MDA-MB-435s cell line was engineered to stably...Go to contribution page
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Dr SEVERINE BRILLOUET (INSTITUT CLAUDIUS REGAUD)12/05/2006, 10:00S9_S10 Molecular ImagingoralAim: Whereas somatostatin receptor scintigraphy has been proven a valuable tool for staging gastrointestinal endocrine tumors, its sensitivity and accuracy in other neoplasm, such as metastatic medullary thyroid cancer (MTC) or small cell lung cancer (SCLC), is limited by the fact that the somatostatin receptors are not expressed in all these tumours and metastasis or that the...Go to contribution page
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Dr Philippe Rizo12/05/2006, 11:00S9_S10 Molecular ImagingoralMolecular imaging allows a better insight of biological mechanisms in vivo, such as the follow-up of gene expression, drugs biodistributions, the assessment of therapies, and can be used for a wide variety of applications, such as cancer, cardiovascular diseases, inflammation… If several techniques such as nuclear medicine (SPECT, TEP), molecular resonance imaging (MRI) and X ray...Go to contribution page
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Dr Evaristo Cisbani (Istituto Superiore di Sanita' - Istituto Nazionale di Fisica Nucleare)12/05/2006, 11:15S9_S10 Molecular ImagingoralRecently there has been a growing interest in molecular imaging techniques by radionuclides. In the imaging techniques panorama incluidng MRI, x-ray CT, optical, etc., they have a specific role due to their unique features. For example, they are extremely sensitive (picomolar) that is needed for imaging biological processes “in vivo”. A wide range of human diseases can be studied in...Go to contribution page
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Dr Marine Soret (U678 Inserm UPMC, HIA Val de Grace)12/05/2006, 11:30S9_S10 Molecular ImagingoralObjectives: Partial volume effect (PVE) is a major source of bias in brain SPECT molecular imaging of dopamine transporter: radioactivity concentration measured within striatal volumes can be underestimated by more than 50% because of PVE only. Various PVE corrections appropriate for SPECT and making use of anatomical data have been developed. These methods yield encouraging results in...Go to contribution page
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Prof. Francesco Scopinaro (Univ. Roma "La Sapienza" - Italy)12/05/2006, 11:45S9_S10 Molecular ImagingoralAim. New radiopharmaceuticals are growing attention for cancer diagnosis and therapy. This work deals with the use of an updated High resolution (HR) camera for small animal imaging. Matherials and Methods. We studied three radiopharmaceuticals: two antibodies (MoAb) and one peptide (P) labelled with 99mTechnetium in 20 rodents. Balb/c nude mice xenografted with cancer cells or T-...Go to contribution page
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Mrs NADIA DJAKER (INSTITUT FRESNEL)12/05/2006, 12:00S9_S10 Molecular ImagingoralKey words: Four-wave mixing, Coherent anti-Stokes Raman scattering (CARS) Microscopy, chemical imaging Coherent anti-Stokes Raman scattering microscopy (CARS) is a new approach for chemical imaging of molecular systems, with high sensitivity, high spatial resolution, and three dimensional sectioning capability, without using fluorophores that are prone to photobleaching. This...Go to contribution page
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