Prof.
David Townsend
(University of Tennessee Graduate School of Medicine)
12/05/2006, 08:30
S9_S10 Molecular Imaging
oral
From autoradiography to planar X-rays, Computed Tomography (CT) and Magnetic
Resonance (MR), morphology and structure has been the mainstay of biological and
medical imaging for over a century. While structural changes may suggest the
presence of disease, functional changes are more sensitive indicators of early-
stage pathology, and where cancer is concerned, early detection is the...
Dr
Keiko Imamura
(Department of Radiology, St. Marianna University School of Medicine)
12/05/2006, 09:00
S9_S10 Molecular Imaging
oral
Regarding that new molecular imaging technologies mostly emerge from isotopic
imaging, it is important to reevaluate preceding technologies of other modalities and
their current role in clinical medicine in order to understand what we presently know
and what are needed.
Among many modalities, MR spectroscopy (MRS) should be reemphasized because it is a
robust in-vivo technique which...
Dr
Hafid BELHADJ-TAHAR
(Groupe Santé Recherche)
12/05/2006, 09:15
S9_S10 Molecular Imaging
oral
Introduction
Cancer constitutes one of the first causes of mortality in the world. This
proliferative disease is characterised by two evolutionary components made of
regional extension and metastatic diffusion. The therapeutic success of cancer
treatment depends on precocity of the diagnosis, of extension assessment and initial
treatment of primitive tumour and its metastatic...
Prof.
John Mertens
(BEFY, Vrije Universiteit Brussel)
12/05/2006, 09:30
S9_S10 Molecular Imaging
oral
The Na+-independent L-type LAT amino acid transport system 1 for neutral and
lipophilic amino acids has been shown to be increased in tumour tissue relative to
normal tissue, and the LAT system has been regarded as a key-point for the
development of new amino acid based tumour tracers for molecular imaging. We have
proven in vitro and in vivo that the new compound 2-I-L-phenylalanine...
Ms
Ya-Fang Chang
(Institute of Radiological Sciences, National Yang-Ming University, Taipei, Taiwan)
12/05/2006, 09:45
S9_S10 Molecular Imaging
oral
Recently, molecular imaging of reporter gene expression provides a rapid,
sensitive, and noninvasive monitoring of tumor behaviors. In this study, we
reported the establishment of novel animal models using immunodeficient mice for
longitudinal examination of tumor growth kinetics and metastatic spreading in vivo.
The highly metastatic MDA-MB-435s cell line was engineered to stably...
Dr
SEVERINE BRILLOUET
(INSTITUT CLAUDIUS REGAUD)
12/05/2006, 10:00
S9_S10 Molecular Imaging
oral
Aim: Whereas somatostatin receptor scintigraphy has been proven a valuable tool for
staging gastrointestinal endocrine tumors, its sensitivity and accuracy in other
neoplasm, such as metastatic medullary thyroid cancer (MTC) or small cell lung
cancer (SCLC), is limited by the fact that the somatostatin receptors are not
expressed in all these tumours and metastasis or that the...
Dr
Philippe Rizo
12/05/2006, 11:00
S9_S10 Molecular Imaging
oral
Molecular imaging allows a better insight of biological mechanisms in vivo, such as
the follow-up of gene expression, drugs biodistributions, the assessment of
therapies, and can be used for a wide variety of applications, such as cancer,
cardiovascular diseases, inflammation…
If several techniques such as nuclear medicine (SPECT, TEP), molecular resonance
imaging (MRI) and X ray...
Dr
Evaristo Cisbani
(Istituto Superiore di Sanita' - Istituto Nazionale di Fisica Nucleare)
12/05/2006, 11:15
S9_S10 Molecular Imaging
oral
Recently there has been a growing interest in molecular imaging techniques by
radionuclides. In the imaging techniques panorama incluidng MRI, x-ray CT, optical,
etc., they have a specific role due to their unique features. For example, they are
extremely sensitive (picomolar) that is needed for imaging biological processes “in
vivo”. A wide range of human diseases can be studied in...
Dr
Marine Soret
(U678 Inserm UPMC, HIA Val de Grace)
12/05/2006, 11:30
S9_S10 Molecular Imaging
oral
Objectives: Partial volume effect (PVE) is a major source of bias in brain SPECT molecular
imaging of dopamine transporter: radioactivity concentration measured within striatal volumes
can be underestimated by more than 50% because of PVE only. Various PVE corrections
appropriate for SPECT and making use of anatomical data have been developed. These
methods yield encouraging results in...
Prof.
Francesco Scopinaro
(Univ. Roma "La Sapienza" - Italy)
12/05/2006, 11:45
S9_S10 Molecular Imaging
oral
Aim. New radiopharmaceuticals are growing attention for cancer diagnosis and
therapy. This work deals with the use of an updated High resolution (HR) camera for
small animal imaging.
Matherials and Methods. We studied three radiopharmaceuticals: two antibodies
(MoAb) and one peptide (P) labelled with 99mTechnetium in 20 rodents. Balb/c nude
mice xenografted with cancer cells or T-...
Mrs
NADIA DJAKER
(INSTITUT FRESNEL)
12/05/2006, 12:00
S9_S10 Molecular Imaging
oral
Key words: Four-wave mixing, Coherent anti-Stokes Raman scattering (CARS)
Microscopy, chemical imaging
Coherent anti-Stokes Raman scattering microscopy (CARS) is a new approach for
chemical imaging of molecular systems, with high sensitivity, high spatial
resolution, and three dimensional sectioning capability, without using fluorophores
that are prone to photobleaching. This...