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Dr Andrea Perrotta (INFN,Dipartimento di Fisica, Bologna)11/05/2006, 14:00Molecular Imaging needs for biologists and physiciansposterRhenium-188 (188Re) represents an interesting radioisotope in cancer therapy for its β- radiation of high energy and γ-ray useful in scintigraphic applications. The genotoxic effect of 188Re-perrhenate has been evaluated on a panel of tumour cell lines (U87,H460,MCF-7,LNCaP,A549,M5076) established from tumors of different type (glioblstoma, lung, breast and prostate cancer) in...Go to contribution page
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Dr Raffaele Scafè (Casaccia Research Center, ENEA, Rome, Italy)11/05/2006, 14:00• New ideasposterThis paper is aimed to describe a sub-miniature scintillation detector suitable for functional inspection of bronchi inside a bronchoscope. The device is made by a probe having diameter adequate for insertion in a bronchial catheter and an external electronics for signal’s analysis. The probe is composed of a scintillation crystal for high-efficiency photon detection and a Si-avalanche...Go to contribution page
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Dr Craig Woody (Brookhaven National Lab)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterA miniature scintillation microprobe has been developed to measure the input function in live rodents for use in longitudinal, quantitative PET studies. The probe consists of a small lutetium oxyorthosilicate (LSO) crystal measuring typically 0.3-0.5 mm diameter x 0.5-2 mm in length that is used to directly detect positrons in the blood or tissue. The probe has a sensitivity of 10-30...Go to contribution page
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Ms Aurélie Desbrée (Laboratoire Imagerie et Modélisation en Neurobiologie et Cancérologie)11/05/2006, 14:00• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)posterElucidating physiological mechanisms in small animal in vivo requires the development of new techniques including imaging with multiple modalities. Combining exploratory techniques has the tremendous advantage to record simultaneously complementary parameters on the same living animal. In this field, an exciting challenge remains in the combination of Nuclear Magnetic Resonance (RMN)...Go to contribution page
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Dr Varlen Grabski (Instituto de Fisica UNAM)11/05/2006, 14:00• New ideasposterA simple method to estimate the coordinate resolution of pixelized detectors using non-single photon counting read out is proposed. This method can be useful particularly for testing the detectors used in digital imaging systems. The traditional technique of determining the coordinate resolution of this type of detectors is mainly based on the use of line spread function measurements that...Go to contribution page
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Dr Andrea Perrotta (Dip. Fisica e INFN, Bologna), Prof. Francesco Navarria (Dip. Fisica e INFN, Bologna)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterThe aim of the SCINTIRAD experiment is to determine the radio-response to 188Re in various cells in vitro, the biodistribution of the radiopharmaceutical in different organs of mice in vivo, and subsequently the therapeutic effect on liver tumours induced in mice inoculated with M5076 murine fibrosarcoma cells. Both the gamma and beta emissions of 188Re have been used in the experiment....Go to contribution page
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Dr Vyacheslav Vinogradov (Institute for Nuclear Reserarch RAS)11/05/2006, 14:00• New ideasposterDevelopment of Electronics, Communication and Computer technologies are moving to full integration of these fields into compact modular systems, integrated by modern networks. High-frequency processor are not more a basic way for advanced high- performance systems and multi core processors become more perspective, and tradition parallel bus based system architectures (VMEbus, cPCI/PXI)...Go to contribution page
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Dr Stephanie PITRE (IMNC, Orsay, France)11/05/2006, 14:00• New ideasposterIn addition to intra-operative probes, compact gamma cameras are very attractive to provide more efficient radio-labeled tumors localization. In this context, our group has developed a high resolution intra-operative imager, POCI (Per-Operative Compact Imager) dedicated to nuclear medicine purposes. The current POCI prototype is based on a 40 mm diameter intensified position sensitive...Go to contribution page
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Dr Laurent MENARD (Laboratoire Imagerie et Modélisation en Neurobiologie et cancérologie (UMR 8165) - Université Paris 7)11/05/2006, 14:00• New ideasposterSurgery is still considered the primary therapeutic procedure for high grade gliomas and several recent clinical studies have shown that gross total tumor resection is directly associated with longer and better survival when compared to subtotal resection. In order to refine the resection especially in the boundaries of gliomas, we are developing an intraoperative probe specifically...Go to contribution page
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Dr Felicia Zito (Nuclear Medicine Department, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy)11/05/2006, 14:00S5-S6 medecineposterObjectives Aim of the present work is to describe and quantitatively assess on reconstructed FDG-PET images, the effects of different levels of detector failures for the HR+, a full ring block designed scanner. Methods All the studies were performed in 2D mode (span 15) with the ECAT EXACT HR+ PET scanner (CTI-Siemens, Knoxville-USA). By using data acquired with PET scanner fully...Go to contribution page
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Dr mohammad reza Ay (Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran and Division of Nuclear Medicine, Geneva University Hospital, Geneva, Switzerland)11/05/2006, 14:00• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)posterThe advent of dual-modality PET/CT imaging had great impact on improving the value of diagnostic PET in localizing, evaluating and therapeutic monitoring of head and neck cancer and equally valuable for other localizations that are difficult to pinpoint. In addition, the use of CT images for CT-based attenuation correction (CTAC) of PET data decreases overall scanning time and creates...Go to contribution page
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Mr Anthony BUTHOD (Institut de Physique Nucléaire de Lyon ( Groupe Imagerie bio-médicale ))11/05/2006, 14:00• New ideasposterThe feasibility of a PET prototype for online and in-situ dose deposition control in hadrontherapy is under study within our group at the “Institut de Physique Nucléaire de Lyon”: IPNL. This is a non conventional use of the PET techniques that would allow a real time non invasive control of the execution of a given cancer treatment plan with heavy charged ionizing particles beam. In...Go to contribution page
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Dr LOICK VERGER (CEA-LETI)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterWe propose here is to study the suitability of a new solid state detector like cadmium telluride (CdTe and CdZnTe) detectors to address the spatial resolution issue associated with small animal Positron Emission Tomography (PET) systems. The main advantage of semi-conducting detectors over scintillation detectors lies in the fact that the segmentation can be obtained very easily thanks...Go to contribution page
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Mr Virgile Bekaert (IPHC/CNRS - ULP)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterThe interest of using small animal imaging has been primarily due to recent advances in genetics with the need to perform longitudinal in vivo studies on mice or rats. Recent works have shown that Single Photon Emission Computed Tomography (SPECT) imaging of small animals can provide high spatial resolution. In our institute, we are developing A Multi modality Imaging System for Small...Go to contribution page
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Dr Pablo Sempere Roldan (Raytest France)11/05/2006, 14:00posterThe ClearPET is a high performance small animal PET scanner that has been developed within the Crystal Clear Collaboration (CCC) and is now commercially available to customers worldwide through the Raytest group (http://www.raytest.com). Its high sensitivity and spatial resolution are achieved thanks to a patented phoswich configuration made of two types of scintillating crystals:...Go to contribution page
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Prof. Roberto Pani (INFN Dept Experimental Medicine and Pathology - University of Rome "La Sapienza"-Italy)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterAlthough scintimammography was introduced more than 10 years ago, it has never become routine in the majority of Nuclear Medicine Centers. The principal limiting factor in the clinical acceptance is certainly its low sensitivity for cancers sized < 1cm, mainly due to the lack of equipment specifically designed for breast imaging. The very low sensitivity of scintimammography for tumors...Go to contribution page
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Ms Ching-Ching Yang (Institute of Radiological Sciences, National Yang-Ming University)11/05/2006, 14:00• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)posterThere are an increasing number of patients with disabling heart conditions related to left ventricular dysfunction, and two thirds of these cases are the result of coronary artery disease. A reduction of mortality and morbidity may be achieved if these diseases can be diagnosed correctly and treated at an early stage before symptoms occur. It is well established that impaired left...Go to contribution page
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Mr Sandor Attila Kis (PET Center, University of Debrecen, Debrecen, Hungary)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterIn-vivo imaging of small laboratory animals is a valuable tool in the development of new drugs. For this purpose miniPET, an easy to scale modular PET camera, has been developed at our institutes. The detector module comprises Hamamatsu R8520 position sensitive PMT and LSO crystal matrix (8 x 8 array of 2 x 2 x 10 mm size). The current system has 4 modules, which makes it possible to...Go to contribution page
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Dr Serge HAAN (CEA)11/05/2006, 14:00Molecular Imaging needs for biologists and physiciansposterFull Title : Molecular Imaging in Tissue and Cells by Computer-assisted Innovative Multimode Mass Spectrometry This project aims to develop new and improved technologies for Molecular Imaging Mass Spectrometry (MIMS), enabling innovative approaches in functional genomics, proteomics and metabolomics, as well as for investigation of cells and tissues. Three objectives are considered...Go to contribution page
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Ms Elodie Breton (Service de Biophysique et Médecine Nucléaire, CHU Hautepierre, 1 av. Molière, 67098 Strasbourg, France)11/05/2006, 14:00• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)posterSmall animal imaging techniques provides the possibility to follow non invasively and in vivo the morphological or functional evolution of a particular organ or tissue over time. The aim of dual imaging is to combine morphological and functional information. Among multimodality imaging techniques for co-registration of mutual information, SPECT/MRI has not, to our knowledge, be applied...Go to contribution page
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20. Early Detection of Tumor Masses in Mice by In Vivo Hematoporphyrin mediated Fluorescence ImagingDr Maddalena Autiero (Università degli studi di Napoli "Federico II")11/05/2006, 14:00• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)posterIn the last years we have tested hematoporphyrin (HP) dichlorohydrate as an optical contrast agent for the in vivo detection of solid surface tumors on small animals (mice) by Fluorescence Reflectance Imaging (FRI). HP dichlorohydrate was shown to accumulate in tumors, but the volume of the studied tumors was about 50-400 mm3, so that the tumor masses were visible with the naked eye...Go to contribution page
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Ms Catarina Ortigão (LIP)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterClearPEM is a project to develop a state of the art Positron Emitting Tomograph dedicated to early breast cancer detection. It is developed by a consortium of Portuguese research institutions within the framework of the Crystal Clear Collaboration. The scanner has a modular architecture, where each detector module features an array of 32 LYSO crystals, with double readout by two pixelated...Go to contribution page
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Dr Antonello Spinelli (Policlinico S. Orsola-Malpighi, Bologna, Italy)11/05/2006, 14:00Molecular Imaging needs for biologists and physiciansposterIntroduction Small animal positron emission tomographs (PET) are becoming extremely popular allowing preclinical investigation of new drugs, new radiotracer etc. by performing several sequential scans on the same animal. In order to compare the results between scans (acquired at different time points) it is necessary to apply quantitative or semi-quantitative image analysis methods....Go to contribution page
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Ms Chia-Lin Chen (National Yang-Ming University)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterMolecular Imaging is an emerging discipline that seeks to exploit our increased understanding of the molecular basis of disease through the design of novel imaging probes to specific molecular targets. Small animal PET offers the unique opportunity to in vivo image small animal models of human diseases noninvasively, repeatedly, and quantitatively in the same animal. Unfortunately,...Go to contribution page
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Prof. Alexander Tcherepanov (senior lecturer)11/05/2006, 14:00• New ideasposterNew method for subject recognition is proposed. We need to know sets of several parameters of assumed subjects for realization of this method. On the base of knowledge about value of these parameters and them distribution characteristics we can say whether investigated subject is assumed subject or no. Parameters of proposed method can have discontinuous or continuous value. In case...Go to contribution page
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Dr Anabela da Silva (Cea-Leti Recherche Technologique)11/05/2006, 14:00• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)posterOptical fluorescent tomography can provide information about the spatial distribution, the lifetime and the concentration of specific fluorescently-labeled cell markers, inserted in highly scattering biological media. 3D fluorescent optical tomography systems are currently developed either with continuous wave, or in the frequency domain or in the time domain. The latter is the one...Go to contribution page
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40. Miniaturized Fibered Confocal Microscopy with the Cell~vizio now enables in vivo in situ imagingMs Anne Osdoit (MKT)11/05/2006, 14:00Molecular Imaging needs for biologists and physiciansposterThe development of the Red Cell~vizio, using a red 635 nm laser, makes it possible to obtain microscopic in vivo images even with the large range of red fluorescent dyes that are widely used in the field of molecular imaging. The Cell~vizio™, based on Fibered Confocal Fluorescence Microscopy, enables in vivo and in situ microscopy down to a resolution of 2.5 µm. Until now, the...Go to contribution page
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Mr Anastasios Karatopis (Department of medical instrumentation,Technological educational institution/2nd Department of Radiology, Medical School, University of Athens)11/05/2006, 14:00S3_S4 others modalitiesoralIn the era of molecular imaging, in-vivo 1H Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) are impacting dramatically upon virtually all areas of clinical medicine. MRS and MRSI should be able to identify key biochemical changes, much before the tumour becomes detectable by other functional imaging methods that mainly rely upon single markers that are not...Go to contribution page
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Ms Ya-ju Hsieh (Institute of Radiological Sciences, National Yang-Ming University, Taiwan)11/05/2006, 14:00Molecular Imaging needs for biologists and physiciansposterAlpha-fetal protein (AFP) is a specific tumor marker for hepatocellular carcinoma (HCC). The gene expression system under AFP promoter/enhancer control would be specific for AFP producing cells, but its low expression level is a problem to be overcome. For the purpose of AFP promoter enhancement for the use of radiation modulated gene therapy, we combined hepatitis B virus (HBV)...Go to contribution page
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Prof. Vladimir Ryzhikov (Institute for Scintillation Materials of STC "Institute for Single Crystals")11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterModern digital radiography and X-ray computer tomography (CT) are among the most efficient methods used for diagnostics of cancer and other diseases requiring surgery. Transition from traditional to dual-energy CT allows separate diagnostics of bone and muscle tissues, i.e., discern between biological materials that substantially differ in their density and atomic number Zeff (by 2-3...Go to contribution page
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Prof. Franck Debardieux (Institut de Biologie du Developpement de Marseille, France), Dr Pierre Delpierre (Centre de Pysique des Particules de Marseille)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterThe PIXSCAN is a small animal CT-scanner based on hybrid pixel detectors. These detectors provide very large dynamic range of photons counting at very low detector noise. They also provide high counting rates with fast image readout. Detection efficiency can be optimized by selecting the sensor medium according to the working energy range. Indeed, the use of CdTe allows a detection...Go to contribution page
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Dr Valéry Matarazzo (IBDML, CNRS-UMR6216, Université de la mediterannée)11/05/2006, 14:00Molecular Imaging needs for biologists and physiciansposterPolysialic acid (PSA) is a long, linear a2-8 linked carbohydrate of N-acetylneuraminic acid residues, added post-translationally to the Neural Cell Adhesion Molecule (NCAM), the prototype of a large family of cell surface Immunoglobulin-like Super-Family (IgSFs) expressed in the nervous system. Polysialylation of NCAM is thought to facilitate cell migration and plasticity by inhibiting...Go to contribution page
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Dr Maria Cristina Montesi (Dipartimento di Scienze Fisiche, Università di Napoli Federico II, and INFN, Sezione di Napoli, I-80126 Napoli, Italy)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterWe report on the tests of a prototype (MediSPECT) for SPECT imaging on small animals with a small field of view (FOV) and high spatial resolution. MediSPECT is a SPECT imaging system based on a 1-mm thick CdTe pixel detector bump-bonded to the Medipix2 CMOS readout circuit operating in single-photon counting developed by the European Medipix2 collaboration. The CdTe detector has...Go to contribution page
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Prof. Roger LECOMTE (Université de Sherbrooke, Nuclear Medicine & Radiobiology)11/05/2006, 14:00S1-S2posterLabPET is a second-generation APD-based PET scanner featuring quasi-individual crystal readout and massively parallel digital processing with advanced signal analysis heuristics for high-performance in vivo molecular imaging of small animals. The system implements several unique features to enhance throughput and facilitate complex imaging protocols in live animals. The basic LabPET...Go to contribution page
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Dr Nicole BARTHE (INSERM U577, Université Victor Segalen Bordeaux 2)11/05/2006, 14:00Molecular Imaging needs for biologists and physiciansposterTwo novel betaimaging systems, particularly interesting in the field of radiopharmacology and molecular biology researches, were developed these last years: (1) a betaimager was derived from researches conducted by Pr Charpak at CERN. This parallel plate avalanche chamber is a direct detection system of radioactivity, which is particularly adapted for qualitative and quantitative...Go to contribution page
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Dr Olivier Devroede (Vrije Universiteit Brussel)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterWe will report result obtained with a ClearPET(TM) Rodent small animal PET scanner at the Vrije Universiteit Brussel (VUB). The ClearPET(TM) scanner was build to be modular. At its basis it consists of cassettes that can contain up to four 64 channel PMTs (Hamamatsu R7600-M64) in line. The scintillator used is a combination of LYSO and LuYAP (each 8mm long), that can be distinguished...Go to contribution page
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Raffaele DE LEO (PHYSICS Department Bari University)11/05/2006, 14:00• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)posterIn the framework of the feasibility studies of the 3D Axial HPD-PET, consisting of axially oriented arrays of long (Lc from 100 to 150 mm) scintillation crystals of small cross section (3.2 x 3.2 mm2) read-out on both sides by a Hybrid Photon Detector (HPD), various investigations are being performed on the features of the crystals to be employed. In fact, the axial spatial, energy,...Go to contribution page
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Dr stefaan Vandenberghe (Ugent)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterDue to the availability of scintillators (LSO, LaBr3) with good timing resolution, sufficient stopping power and good energy resolution, different 3D TOF PET scanners are now under development. Recently we have shown that improved timing resolution allows to reduce the number of angles needed to reconstruct TOF-PET data. Histoprojections from TOF data can be seen as an asymmetrically...Go to contribution page
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Dr Nicolas Sandeau (Institut Fresnel)11/05/2006, 14:00Molecular Imaging needs for biologists and physiciansposterKeywords: Fluorescence Confocal Microscopy, 4Pi-microscopy, Molecular Detection Efficiency Function, Lateral Resolution, Axial Resolution. Improving the spatial resolution in optical microscopes is a challenging task for many applications. In fluorescence confocal microscopy the resolution is given by the Detection Efficiency Function (DEF) resulting from the product of the Excitation...Go to contribution page
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Mrs Marina TAVERNE (IPNL groupe imagerie médicale)11/05/2006, 14:00• New ideasposterOur group at the “Institut de Physique Nucléaire de Lyon” (IPNL) is working for physics and detectors for medical imaging. We are presently developing, for a demonstration purpose and within the Crystal Clear international collaboration, a small animal PET scanner that should have enhanced slow control and data acquisition features. We also investigate a feasibility study of an online...Go to contribution page
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Ms Chia-Chi Chen (Cancer Research Division, National Health Research Institute, Zhunan, Taiwan), Ms Ya Fang Chang (Institute of Radiological Sciences, National Yang-Ming University)11/05/2006, 14:00Molecular Imaging needs for biologists and physiciansposterIn vivo bioluminescence imaging (BLI) is a sensitive imaging modality that is rapid and accessible, and may comprise an ideal tool for evaluating tumor growth. In this study, the kinetic of tumor growth has been assessed in C26 colon carcinoma bearing Balb/C mouse model. The ability of BLI to noninvasively quantitate the growth of subcutaneous tumors transplanted with C26 cells...Go to contribution page
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Dr Efstathios Stiliaris (University of Athens & IASA)11/05/2006, 14:00• Status of animal and clinical PET, SPECT and CT (biomedical and technical)posterThe experimental program of the SPECT group at the Institute of Accelerating Systems & Applications (IASA) will be presented. It is mainly focused on the development of a new small field of view gamma-Camera based on a Position Sensitive Photomultiplier Tube with pixelized CsI(Tl) and NaI(Tl) scintillation crystals using modern Data Acquisition systems, which are designed on commercially...Go to contribution page
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