Dr
Andrea Perrotta
(INFN,Dipartimento di Fisica, Bologna)
11/05/2006, 14:00
Molecular Imaging needs for biologists and physicians
poster
Rhenium-188 (188Re) represents an interesting radioisotope in cancer therapy for
its β- radiation of high
energy and γ-ray useful in scintigraphic applications. The genotoxic effect of
188Re-perrhenate has been
evaluated on a panel of tumour cell lines (U87,H460,MCF-7,LNCaP,A549,M5076)
established from tumors of
different type (glioblstoma, lung, breast and prostate cancer) in...
Dr
Raffaele Scafè
(Casaccia Research Center, ENEA, Rome, Italy)
11/05/2006, 14:00
• New ideas
poster
This paper is aimed to describe a sub-miniature scintillation detector suitable for
functional inspection of bronchi inside a bronchoscope. The device is made by a
probe having diameter adequate for insertion in a bronchial catheter and an
external electronics for signal’s analysis. The probe is composed of a
scintillation crystal for high-efficiency photon detection and a Si-avalanche...
Dr
Craig Woody
(Brookhaven National Lab)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
A miniature scintillation microprobe has been developed to measure the input function
in live rodents for use in longitudinal, quantitative PET studies. The probe consists
of a small lutetium oxyorthosilicate (LSO) crystal measuring typically 0.3-0.5 mm
diameter x 0.5-2 mm in length that is used to directly detect positrons in the blood
or tissue. The probe has a sensitivity of 10-30...
Ms
Aurélie Desbrée
(Laboratoire Imagerie et Modélisation en Neurobiologie et Cancérologie)
11/05/2006, 14:00
• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)
poster
Elucidating physiological mechanisms in small animal in vivo requires the
development of new techniques including imaging with multiple modalities. Combining
exploratory techniques has the tremendous advantage to record simultaneously
complementary parameters on the same living animal. In this field, an exciting
challenge remains in the combination of Nuclear Magnetic Resonance (RMN)...
Dr
Varlen Grabski
(Instituto de Fisica UNAM)
11/05/2006, 14:00
• New ideas
poster
A simple method to estimate the coordinate resolution of pixelized detectors using
non-single photon counting read out is proposed. This method can be useful
particularly for testing the detectors used in digital imaging systems. The
traditional technique of determining the coordinate resolution of this type of
detectors is mainly based on the use of line spread function measurements that...
Dr
Andrea Perrotta
(Dip. Fisica e INFN, Bologna), Prof.
Francesco Navarria
(Dip. Fisica e INFN, Bologna)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
The aim of the SCINTIRAD experiment is to determine the radio-response to 188Re in various cells in vitro,
the biodistribution of the radiopharmaceutical in different organs of mice in vivo, and subsequently the
therapeutic effect on liver tumours induced in mice inoculated with M5076 murine fibrosarcoma cells.
Both the gamma and beta emissions of 188Re have been used in the experiment....
Dr
Vyacheslav Vinogradov
(Institute for Nuclear Reserarch RAS)
11/05/2006, 14:00
• New ideas
poster
Development of Electronics, Communication and Computer technologies are moving to
full integration of these fields into compact modular systems, integrated by modern
networks. High-frequency processor are not more a basic way for advanced high-
performance systems and multi core processors become more perspective, and tradition
parallel bus based system architectures (VMEbus, cPCI/PXI)...
Dr
Stephanie PITRE
(IMNC, Orsay, France)
11/05/2006, 14:00
• New ideas
poster
In addition to intra-operative probes, compact gamma cameras are very attractive to
provide more efficient radio-labeled tumors localization. In this context, our
group has developed a high resolution intra-operative imager, POCI (Per-Operative
Compact Imager) dedicated to nuclear medicine purposes. The current POCI prototype
is based on a 40 mm diameter intensified position sensitive...
Dr
Laurent MENARD
(Laboratoire Imagerie et Modélisation en Neurobiologie et cancérologie (UMR 8165) - Université Paris 7)
11/05/2006, 14:00
• New ideas
poster
Surgery is still considered the primary therapeutic procedure for high grade gliomas
and several recent clinical studies have shown that gross total tumor resection is
directly associated with longer and better survival when compared to subtotal
resection. In order to refine the resection especially in the boundaries of gliomas,
we are developing an intraoperative probe specifically...
Dr
Felicia Zito
(Nuclear Medicine Department, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy)
11/05/2006, 14:00
S5-S6 medecine
poster
Objectives
Aim of the present work is to describe and quantitatively assess on reconstructed
FDG-PET images, the effects of different levels of detector failures for the HR+, a
full ring block designed scanner.
Methods
All the studies were performed in 2D mode (span 15) with the ECAT EXACT HR+ PET
scanner (CTI-Siemens, Knoxville-USA). By using data acquired with PET scanner fully...
Dr
mohammad reza Ay
(Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran and Division of Nuclear Medicine, Geneva University Hospital, Geneva, Switzerland)
11/05/2006, 14:00
• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)
poster
The advent of dual-modality PET/CT imaging had great impact on improving the value
of diagnostic PET in localizing, evaluating and therapeutic monitoring of head and
neck cancer and equally valuable for other localizations that are difficult to
pinpoint. In addition, the use of CT images for CT-based attenuation correction
(CTAC) of PET data decreases overall scanning time and creates...
Mr
Anthony BUTHOD
(Institut de Physique Nucléaire de Lyon ( Groupe Imagerie bio-médicale ))
11/05/2006, 14:00
• New ideas
poster
The feasibility of a PET prototype for online and in-situ dose deposition control in
hadrontherapy is under study within our group at the “Institut de Physique Nucléaire
de Lyon”: IPNL. This is a non conventional use of the PET techniques that would allow
a real time non invasive control of the execution of a given cancer treatment plan
with heavy charged ionizing particles beam. In...
Dr
LOICK VERGER
(CEA-LETI)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
We propose here is to study the suitability of a new solid state detector like
cadmium telluride (CdTe and CdZnTe) detectors to address the spatial resolution
issue associated with small animal Positron Emission Tomography (PET) systems. The
main advantage of semi-conducting detectors over scintillation detectors lies in the
fact that the segmentation can be obtained very easily thanks...
Mr
Virgile Bekaert
(IPHC/CNRS - ULP)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
The interest of using small animal imaging has been primarily due to recent advances
in genetics with the need to perform longitudinal in vivo studies on mice or rats.
Recent works have shown that Single Photon Emission Computed Tomography (SPECT)
imaging of small animals can provide high spatial resolution. In our institute, we
are developing A Multi modality Imaging System for Small...
Dr
Pablo Sempere Roldan
(Raytest France)
11/05/2006, 14:00
poster
The ClearPET is a high performance small animal PET scanner that has been developed
within the Crystal Clear Collaboration (CCC) and is now commercially available to
customers worldwide through the Raytest group (http://www.raytest.com).
Its high sensitivity and spatial resolution are achieved thanks to a patented
phoswich configuration made of two types of scintillating crystals:...
Prof.
Roberto Pani
(INFN Dept Experimental Medicine and Pathology - University of Rome "La Sapienza"-Italy)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
Although scintimammography was introduced more than 10 years ago, it has never become
routine in the majority of Nuclear Medicine Centers. The principal limiting factor in
the clinical acceptance is certainly its low sensitivity for cancers sized < 1cm,
mainly due to the lack of equipment specifically designed for breast imaging. The
very low sensitivity of scintimammography for tumors...
Ms
Ching-Ching Yang
(Institute of Radiological Sciences, National Yang-Ming University)
11/05/2006, 14:00
• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)
poster
There are an increasing number of patients with disabling heart conditions related
to left ventricular dysfunction, and two thirds of these cases are the result of
coronary artery disease. A reduction of mortality and morbidity may be achieved if
these diseases can be diagnosed correctly and treated at an early stage before
symptoms occur. It is well established that impaired left...
Mr
Sandor Attila Kis
(PET Center, University of Debrecen, Debrecen, Hungary)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
In-vivo imaging of small laboratory animals is a valuable tool in the development of
new drugs. For this purpose miniPET, an easy to scale modular PET camera, has been
developed at our institutes. The detector module comprises Hamamatsu R8520 position
sensitive PMT and LSO crystal matrix (8 x 8 array of 2 x 2 x 10 mm size). The current
system has 4 modules, which makes it possible to...
Dr
Serge HAAN
(CEA)
11/05/2006, 14:00
Molecular Imaging needs for biologists and physicians
poster
Full Title : Molecular Imaging in Tissue and Cells by Computer-assisted Innovative
Multimode Mass Spectrometry
This project aims to develop new and improved technologies for Molecular Imaging
Mass Spectrometry (MIMS), enabling innovative approaches in functional genomics,
proteomics and metabolomics, as well as for investigation of cells and tissues.
Three objectives are considered...
Ms
Elodie Breton
(Service de Biophysique et Médecine Nucléaire, CHU Hautepierre, 1 av. Molière, 67098 Strasbourg, France)
11/05/2006, 14:00
• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)
poster
Small animal imaging techniques provides the possibility to follow non invasively and
in vivo the morphological or functional evolution of a particular organ or tissue
over time. The aim of dual imaging is to combine morphological and functional
information. Among multimodality imaging techniques for co-registration of mutual
information, SPECT/MRI has not, to our knowledge, be applied...
20.
Early Detection of Tumor Masses in Mice by In Vivo Hematoporphyrin mediated Fluorescence Imaging
Dr
Maddalena Autiero
(Università degli studi di Napoli "Federico II")
11/05/2006, 14:00
• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)
poster
In the last years we have tested hematoporphyrin (HP) dichlorohydrate as an optical
contrast agent for the in vivo detection of solid surface tumors on small animals
(mice) by Fluorescence Reflectance Imaging (FRI). HP dichlorohydrate was shown to
accumulate in tumors, but the volume of the studied tumors was about 50-400 mm3, so
that the tumor masses were visible with the naked eye...
Ms
Catarina Ortigão
(LIP)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
ClearPEM is a project to develop a state of the art Positron Emitting Tomograph
dedicated to early breast cancer detection. It is developed by a consortium of
Portuguese research institutions within the framework of the Crystal Clear
Collaboration. The scanner has a modular architecture, where each detector module
features an array of 32 LYSO crystals, with double readout by two pixelated...
Dr
Antonello Spinelli
(Policlinico S. Orsola-Malpighi, Bologna, Italy)
11/05/2006, 14:00
Molecular Imaging needs for biologists and physicians
poster
Introduction
Small animal positron emission tomographs (PET) are becoming extremely popular
allowing preclinical investigation of new drugs, new radiotracer etc. by performing
several sequential scans on the same animal. In order to compare the results
between scans (acquired at different time points) it is necessary to apply
quantitative or semi-quantitative image analysis methods....
Ms
Chia-Lin Chen
(National Yang-Ming University)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
Molecular Imaging is an emerging discipline that seeks to exploit our increased
understanding of the molecular basis of disease through the design of novel imaging
probes to specific molecular targets. Small animal PET offers the unique
opportunity to in vivo image small animal models of human diseases noninvasively,
repeatedly, and quantitatively in the same animal. Unfortunately,...
Prof.
Alexander Tcherepanov
(senior lecturer)
11/05/2006, 14:00
• New ideas
poster
New method for subject recognition is proposed. We need to know sets of several
parameters of assumed subjects for realization of this method. On the base of
knowledge about value of these parameters and them distribution characteristics we
can say whether investigated subject is assumed subject or no.
Parameters of proposed method can have discontinuous or continuous value. In case...
Dr
Anabela da Silva
(Cea-Leti Recherche Technologique)
11/05/2006, 14:00
• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)
poster
Optical fluorescent tomography can provide information about the spatial
distribution, the lifetime and the concentration of specific fluorescently-labeled
cell markers, inserted in highly scattering biological media. 3D fluorescent
optical tomography systems are currently developed either with continuous wave, or
in the frequency domain or in the time domain. The latter is the one...
40.
Miniaturized Fibered Confocal Microscopy with the Cell~vizio now enables in vivo in situ imaging
Ms
Anne Osdoit
(MKT)
11/05/2006, 14:00
Molecular Imaging needs for biologists and physicians
poster
The development of the Red Cell~vizio, using a red 635 nm laser, makes it possible to
obtain microscopic in vivo images even with the large range of red fluorescent dyes
that are widely used in the field of molecular imaging.
The Cell~vizio™, based on Fibered Confocal Fluorescence Microscopy, enables in vivo
and in situ microscopy down to a resolution of 2.5 µm. Until now, the...
Mr
Anastasios Karatopis
(Department of medical instrumentation,Technological educational institution/2nd Department of Radiology, Medical School, University of Athens)
11/05/2006, 14:00
S3_S4 others modalities
oral
In the era of molecular imaging, in-vivo 1H Magnetic resonance spectroscopy (MRS)
and spectroscopic imaging (MRSI) are impacting dramatically upon virtually all
areas of clinical medicine. MRS and MRSI should be able to identify key biochemical
changes, much before the tumour becomes detectable by other functional imaging
methods that mainly rely upon single markers that are not...
Ms
Ya-ju Hsieh
(Institute of Radiological Sciences, National Yang-Ming University, Taiwan)
11/05/2006, 14:00
Molecular Imaging needs for biologists and physicians
poster
Alpha-fetal protein (AFP) is a specific tumor marker for hepatocellular carcinoma
(HCC). The gene expression system under AFP promoter/enhancer control would be
specific for AFP producing cells, but its low expression level is a problem to be
overcome. For the purpose of AFP promoter enhancement for the use of radiation
modulated gene therapy, we combined hepatitis B virus (HBV)...
Prof.
Vladimir Ryzhikov
(Institute for Scintillation Materials of STC "Institute for Single Crystals")
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
Modern digital radiography and X-ray computer tomography (CT) are among the most
efficient methods used for diagnostics of cancer and other diseases requiring
surgery. Transition from traditional to dual-energy CT allows separate diagnostics of
bone and muscle tissues, i.e., discern between biological materials that
substantially differ in their density and atomic number Zeff (by 2-3...
Prof.
Franck Debardieux
(Institut de Biologie du Developpement de Marseille, France), Dr
Pierre Delpierre
(Centre de Pysique des Particules de Marseille)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
The PIXSCAN is a small animal CT-scanner based on hybrid pixel detectors. These
detectors provide very large dynamic range of photons counting at very low detector
noise. They also provide high counting rates with fast image readout. Detection
efficiency can be optimized by selecting the sensor medium according to the working
energy range. Indeed, the use of CdTe allows a detection...
Dr
Valéry Matarazzo
(IBDML, CNRS-UMR6216, Université de la mediterannée)
11/05/2006, 14:00
Molecular Imaging needs for biologists and physicians
poster
Polysialic acid (PSA) is a long, linear a2-8 linked carbohydrate of
N-acetylneuraminic acid residues, added post-translationally to the Neural Cell
Adhesion Molecule (NCAM), the prototype of a large family of cell surface
Immunoglobulin-like Super-Family (IgSFs) expressed in the nervous system.
Polysialylation of NCAM is thought to facilitate cell migration and plasticity by
inhibiting...
Dr
Maria Cristina Montesi
(Dipartimento di Scienze Fisiche, Università di Napoli Federico II, and INFN, Sezione di Napoli, I-80126 Napoli, Italy)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
We report on the tests of a prototype (MediSPECT) for SPECT imaging on small
animals with a small field of view (FOV) and high spatial resolution. MediSPECT is
a SPECT imaging system based on a 1-mm thick CdTe pixel detector bump-bonded to the
Medipix2 CMOS readout circuit operating in single-photon counting developed by the
European Medipix2 collaboration. The CdTe detector has...
Prof.
Roger LECOMTE
(Université de Sherbrooke, Nuclear Medicine & Radiobiology)
11/05/2006, 14:00
S1-S2
poster
LabPET is a second-generation APD-based PET scanner featuring quasi-individual
crystal readout and massively parallel digital processing with advanced signal
analysis heuristics for high-performance in vivo molecular imaging of small
animals. The system implements several unique features to enhance throughput and
facilitate complex imaging protocols in live animals. The basic LabPET...
Dr
Nicole BARTHE
(INSERM U577, Université Victor Segalen Bordeaux 2)
11/05/2006, 14:00
Molecular Imaging needs for biologists and physicians
poster
Two novel betaimaging systems, particularly interesting in the field of
radiopharmacology and molecular biology researches, were developed these last
years:
(1) a betaimager was derived from researches conducted by Pr Charpak at CERN. This
parallel plate avalanche chamber is a direct detection system of radioactivity,
which is particularly adapted for qualitative and quantitative...
Dr
Olivier Devroede
(Vrije Universiteit Brussel)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
We will report result obtained with a ClearPET(TM) Rodent small animal PET scanner
at the Vrije Universiteit Brussel (VUB). The ClearPET(TM) scanner was build to be
modular. At its basis it consists of cassettes that can contain up to four 64
channel PMTs (Hamamatsu R7600-M64) in line. The scintillator used is a
combination of LYSO and LuYAP (each 8mm long), that can be distinguished...
Raffaele DE LEO
(PHYSICS Department Bari University)
11/05/2006, 14:00
• Biomedical perspectives and technical challenges for morpho-functional imaging (multimodality : PET/CT,SPECT/CT,PET/MRI,SPECT/MRI ...)
poster
In the framework of the feasibility studies of the 3D Axial HPD-PET, consisting of
axially oriented arrays of long (Lc from 100 to 150 mm) scintillation crystals of
small cross section (3.2 x 3.2 mm2) read-out on both sides by a Hybrid Photon
Detector (HPD), various investigations are being performed on the features of the
crystals to be employed. In fact, the axial spatial, energy,...
Dr
stefaan Vandenberghe
(Ugent)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
Due to the availability of scintillators (LSO, LaBr3) with good timing resolution, sufficient stopping power and
good energy resolution, different 3D TOF PET scanners are now under development. Recently we have
shown that improved timing resolution allows to reduce the number of angles needed to reconstruct TOF-PET
data. Histoprojections from TOF data can be seen as an asymmetrically...
Dr
Nicolas Sandeau
(Institut Fresnel)
11/05/2006, 14:00
Molecular Imaging needs for biologists and physicians
poster
Keywords: Fluorescence Confocal Microscopy, 4Pi-microscopy, Molecular Detection
Efficiency Function, Lateral Resolution, Axial Resolution.
Improving the spatial resolution in optical microscopes is a challenging task for
many applications. In fluorescence confocal microscopy the resolution is given by
the Detection Efficiency Function (DEF) resulting from the product of the Excitation...
Mrs
Marina TAVERNE
(IPNL groupe imagerie médicale)
11/05/2006, 14:00
• New ideas
poster
Our group at the “Institut de Physique Nucléaire de Lyon” (IPNL) is working for
physics and detectors for medical imaging. We are presently developing, for a
demonstration purpose and within the Crystal Clear international collaboration, a
small animal PET scanner that should have enhanced slow control and data acquisition
features. We also investigate a feasibility study of an online...
Ms
Chia-Chi Chen
(Cancer Research Division, National Health Research Institute, Zhunan, Taiwan), Ms
Ya Fang Chang
(Institute of Radiological Sciences, National Yang-Ming University)
11/05/2006, 14:00
Molecular Imaging needs for biologists and physicians
poster
In vivo bioluminescence imaging (BLI) is a sensitive imaging modality that is rapid
and accessible, and may comprise an ideal tool for evaluating tumor growth. In this
study, the kinetic of tumor growth has been assessed in C26 colon carcinoma bearing
Balb/C mouse model. The ability of BLI to noninvasively quantitate the growth of
subcutaneous tumors transplanted with C26 cells...
Dr
Efstathios Stiliaris
(University of Athens & IASA)
11/05/2006, 14:00
• Status of animal and clinical PET, SPECT and CT (biomedical and technical)
poster
The experimental program of the SPECT group at the Institute of Accelerating Systems
& Applications (IASA) will be presented. It is mainly focused on the development of a
new small field of view gamma-Camera based on a Position Sensitive Photomultiplier
Tube with pixelized CsI(Tl) and NaI(Tl) scintillation crystals using modern Data
Acquisition systems, which are designed on commercially...
