Description
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Nanotechnology are beneficial for safe and efficient consumption of food, water and agricultural products. The NANOTEC-CU center of excellent on food and agriculture has focused the research in molecular design, synthesis and fabrication of nanomaterials for applications in the field of food and agriculture including chemical analysis and delivery systems. Various chromophores and fluorophores...
Nanocellulose is a cellulose-based material that possesses at least one of its dimensions in the nanometer range. Due to its unique characteristics, including its excellent mechanical properties, high degrees of thermal stability and water holding capacity, biodegradability and biocompatibility, nanocellulose is a promising naturally-derived material that can be used for various biomedical as...
Elongating filaments systems, such as actin, are polymerizing motors that drive movement in many biological processes. The actin filament is astonishingly well conserved across a diverse set of eukaryotic species. It has essentially remained unchanged in the billion years that separate yeast, Arabidopsis and man. In contrast, bacterial actin-like proteins have diverged to the extreme, many of...
The feasibility of using lime residues after juice extraction as a raw material to produce nanocellulose was determined in this study. Different processing schemes were applied by varying the pretreatment and defibrillation methods and conditions. Autoclaving at 110-130 C was performed as a pretreatment to remove hemicellulose and pectin from the native fiber. The fiber images obtained from...
Caffeic acid phenethyl ester was successfully prepared by rapid expansion of supercritical solutions into liquid solvent. An average size of these CAPE nanoparticles was characterized by TEM and DLS techniques. They were found that diameters CAPE-NPs were ~40 to ~400 nm. The minimum inhibitory concentrations (MICs) and the minimum bactericidal concentration (MBCs) of CAPE nanoparticles were...
Cancer is the leading cause of death in Thailand. Despite advances in cancer research during the past decades, the survival of cancer patients has only marginally improved and the cure remains unlikely. Complex genomic heterogeneity and limited drug delivery represent major obstacles for effective antineoplastic treatments. Thus, new therapeutic strategies to increase drug delivery may improve...
Poor oral absorption and rapid enzymatic degradation are the major hurdles in to deliver peptide drugs orally and vaccines via the mucosa. We developed stable, orally available peptide drugs through the chemical addition of specifically designed lipids and carbohydrates, creating amphiphilic compounds capable to reassemble to form nanoparticles.Fertility is controlled by decreasing the level...
Nanotechnology and Health
Teerapol Srichana
NANOTEC-PSU Excellence Centre on Drug Delivery System, Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkla 90112, Thailand
Email address: teerapol.s@psu.ac.th
Nanomedicine and nanotechnology provides an early detection and prevention of diseases resulting in improved...
Highly sensitive detection is a major goal for sensing and/or diagnosis of diseases, food-borne bacteria and biological warfare agents. High specific and sensitive detections can be achieved via labeling techniques in DNA hybridization and antibody-antigen interaction. Labels based on nanoscale materials open a new opportunity over the traditional methods - in terms of greater reporting signal...
Abstract
By the use of nanotechnology in the development of bioassay kit, the ideal goals that inevitable are rapid, convenience and cost effective. Through our knowledge toward Human Immunodeficiency Virus-1/Acquire Immunodeficiency Disease (HIV-1/AIDS), we successfully produced a novel test kit for investigating both of HIV protease activity and HIV-1 protease inhibitors (PIs). This...
Nanocatalysts have played an important role in biorefinery and advanced biofuel applications. The conversion of cellulosic biomass feedstocks to platform biochemicals, such as organic acids and furans, is one of the key steps in biorefining. In our research group, metal phosphate catalysts have been developed for production of 5-hydroxymethylfurfural from C6 sugar. Incorporating metal species...
A simple thermal oxidation has been used for fabricating nanostructured NiO/NFs electrodes at a temperature lower 1000 ͦC in air. The results obtained from x-ray diffraction (XRD) and scanning electron microscope (SEM) have shown the structure and morphology of Ni foam (NFs) before and after oxidation. The electrochemical characterization measurements have shown that the NiO/NFs electrodes are...
Deoxygenation of vegetable oil has been employed as one of important processes for highly efficient production of renewable green diesel (bio-hydrogenated diesel). Moreover, to avoiding sulfur contamination in fuel product, metal oxides, metal phosphides, and metal nitrides have become attractive. In this work, bimetal oxide catalysts over supported alumina were selected to produce...
The external magnetic field was applied in a packed-bed reactor based on the concepts of green and sustainable production of alternative fuels through CO2 hydrogenation reaction. Accordingly, the roles of magnetic flux density and magnetic field direction on the performance of Fe-Cu/MCM-41 catalyst with intrinsic magnetic property were investigated and compared to that of without magnetic...
Cellulose, extracted from plant, has been widely used in various purposes especially in paper industry. In industry, cellulose is modified by many organic and inorganic substances in order to improve the quality like smoothness, whiteness and mechanical strength. However the deterioration of the paper according to the degradation of cellulose has been found in many ancient documents and...
The new composite materials of TiO2 nanoparticles and biomolecules are promising to provide the potential alternative for improving the photocatalytic activity by merging the ability and features of both material types. In this research, the unique visible light-responsive chlorophyll and magnesium (Mg) co-modified P25 catalyst (Chl-Mg/P25) was successfully synthesized by using a simple...
Smell, taste, appearance and flavor are central to the value of agricultural products, especially fruits and their post-harvest spin-offs such as teas, coffees and wines. In specific, the uniqueness of a wine depends on types and ratio of such aroma molecules collected in the leaves or fruits during the growing seasons, which is related to many external factors such as soil conditions,...
In this paper, gold nanoparticles were synthesized by means of a green approach with T. triandra leaf extracts under different conditions. No additional reducing or capping agents were employed. The gold nanoparticles were characterized using UV-visible spectrometry, transmission electron microscope, X-ray diffraction and Fourier transform infrared spectroscopy. Gold nanoparticles that had...
A highly sensitive turn-on fluorescent sensor for cyanide was developed based on benzylidenes containing methylindolium group. Three benzylidene derivatives were synthesized from the condensation reactions between benzaldehyde derivatives and methyleneindoline. Only one of these three derivatives shows strong visible blue fluorescence selectively to cyanide which was clearly observed in...
Fluorescent-based sensors have received extensive attention due to its highly sensitive and rapid sensing ability to detect metal ions. In this study, we have developed a new BODIPY derivative, mTBODdiSalic for detection of metal ions in aqueous media. The probe has been synthesized from 2,4-dimethylpyrrole and 5-formylsalicylic acid in 4 steps and fully characterized with NMR and Mass...
Silver nanoparticles (Ag-NPs) were impregnated on the surface of coffee grounds (CF) (referred to as Ag-CF hybrid, having 0.44 and 0.80 % weight of Ag), for achieving water disinfection in a batch set-up. First, Ag-CF was synthesized by coating with nature-inspired nanoparticles that containing Ag-NPs on their surface. Subsequently, Escherichia coli and Staphylococcus aureus cells-killing...
A composite film of Cassava root and Poly (3,4-ethylenedioxy thiophene):polystyrene sulfonate (C/PEDOT:PSS) was prepared as a high electrocatalytic material for the counter electrode (CE) of a dye-sensitized solar cell (DSSC). The effect of sintered of Cassava root under Ar atmosphere at 1000 $^o$C was intended for increasing the conductivity, and the PEDOT:PSS was used for a strong adhesion...
In this work, high efficient sensor array for sweet taste classification was demonstrated for electronic tongue application. The sensor array was fabricated by electrochemical sensors based on multiwall carbon nanotube (MWCNT) paste blending with modify electroactive species including either nickel oxide (NiO), copper oxide (CuO), cobalt phthalocynine (CoPC) or iron phthalocyanine (FePC). The...
We have designed a complete-antibody-like construct where the CL and CH1 domains of trastuzumab are exchanged for a pair of CH3 domains and efficient heterodimerization of the light and the heavy chain is achieved using “Knobs-into-Holes” strategy. The construct prepared in this way expressed at a high level in HEK293 system. Rational mutagenesis of the amino acid residues located at the...
SHuffle is a genetically engineered E.coli strain that allows disulfide bond formation in its cytoplasm with high fidelity. Many proteins containing disulfide bonds have been successfully expressed in SHuffle. In this study, we have expressed for the first time full length human, rabbit and mouse antibodies, along with chimeric versions, including the commercial blockbuster Humira in SHuffle...
Nanomaterials have received unceasingly consideration for decades. Profuse utilizations have been afforded to raise the efficacy of research in numerous scientific fields since their discovery. This novel supplies trigger the versatility of materials properties in which diversely expedite the applications in analytical research. Due to exceptional features derived from indigenous of particles...
Selective Permeability of Antimicrobial Agents through the Protein Nanopore of the Highly-Drug Resistant Melioidosis Bacterium Burkholderia pseudomallei
Anuwat Aunkhum, 2 and Wipa Suginta*1 ,2
1Biochemistry-Electrochemistry Research Unit, Suranaree University of Technology, Nakhon Ratchasima, Thailand
2School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon...
Here we developed a fluorescent probe for in vivo colorectal cancer detection using Cy5-doped silica nanoparticles (Cy5-SiNPs) conjugated to monoclonal antibody (mAb) with controlled orientation. Monoclonal antibody specific to anti-epithelial cell adhesion molecule (EpCAM), a cell surface protein overexpressed in colorectal carcinoma, was conjugated on the Cy5-SiNPs coated with protein G...
Material surface properties are considered as critical factor for the study of in Vitro cell growth pattern and activities. It provides advantages not only for study of cellular activity but also for biomedical technology such as tissue engineering. Neuron is a typical cell type widely used to examine cell communication, alignment and differentiations. In the present study, a simple pattern...
Cosmeceuticals from natural products or herbal cosmetics has become the most topic of interest in nowadays cosmetic trend, as they are natural, safe and free from all the harmful synthetic chemicals. Many naturally available herbs serves as active ingredients in different uses for skincare, haircare and antioxidant formulation. However, the application of phytochemical extracts in...
Over the last several decades, there has been tremendous amount of interest in developing novel nanoparticles for drug delivery to cancers. These nanoparticle platforms can be categorized as organic-based (e.g., lipid nanoparticles, biodegradable polymeric nanoparticles, and viral vectors), inorganic-based (e.g., metallic nanostructures, silica nanopartices, and quantum dots), or a hybrid...
A simple electrochemical aptasensor was developed for the detection of glycated albumin (GHSA) using ssDNA aptamer that selectively binds to GHSA as a recognition element. The biotinylated ssDNA aptamer was immobilized on a streptavidin-modified screen-printed carbon electrode (SPCE). The changes of interfacial features of the electrode surface, which were based on the aptamer-GHSA...
Magnetofection, a site-specific delivery of nucleic acids to cells guided by a magnetic field, has received increasing attention for its great potential on gene therapy. To promote its clinical therapeutic applications, development of safe and effective magnetic nanocarriers is in high demand. Superparamagnetic iron oxide (SPIO) nanoparticles have been clinically proven safe and used as a...
Diabetes has been one of the major health issues worldwide and also in Thailand. More importantly, almost half of those with diabetes are undiagnosed. Although various test methods have been developed, the existence of anemia and thalassemia may cause inaccuracy in the diabetes mellitus testing from blood. An alternative biomarker molecule is glycated albumin which directly corresponds to the...
As a natural-derived phenolic compound, quercetin has promisingly strong antioxidant activities. It is possible to incorporate this compound with active packaging film. However quercetin has poor water-solubility resulting in a limitation of its antioxidant efficacy. Nanotechnology is one of the innovative technologies that can increase surface area, bioactivity, and also improve the...
