Nextcloud can be scaled from very small to very big installations. This talk gives an insiders look on how to deploy, run and scale Nextcloud in different scenarios. Discussed will be a very big installation in the research space, an installation in a global enterprise and the implementation of Nextcloud at one of the largest service providers in the world. The different infrastructural choices of servers, databases, storage backends, operating systems and other architectural differences are presented and compared. Also the various requirements around scalability, performance, high availability, backup, costs and functionality are considered.