Speaker
Sebastian Kozerke
Description
Dissolution dynamic nuclear polarization allows to temporarily enhance polarization of
carbon-13 and other nuclei by up to four orders of magnitude and yields injectable tracers in solution for in-vivo
applications. In recent years, various substrates have been proposed to probe different metabolic pathways or to
act as inert contrast agents. To this end, we show work on long-lived polarization in silicon-29 and its
potential for in-vivo imaging. We demonstrate advanced imaging approaches of pyruvate and urea along with
modelling to assess relevant biological information in both the experimental and human setting and provide an outlook towards optimal experimental design.
