Pulse sequences in solid-state NMR are usually designed and simulated using the assumption of perfect rectangular or shaped pulses. Since the early 50s it had been recognized that the limited bandwidth of the resonance circuit leads to pulse transients (amplitude and phase) at discontinuities of the phase or amplitude. Therefore, the rotations that the spins experience are not the same as the...
Various polymeric drug delivery systems suitable for physical entrapment of porphyrinic photosensitizers are a focus of our research. In this presentation, it will be shown how NMR can provide useful information on many different aspects such as drug loading and stability of the porphyrin-carrier systems. Classical NMR spectroscopic methods such as NOESY and DOSY are used to analyze drug...
Nitrogen-Vacancy centers in diamond are fluorescent crystal defects with a unique property: Their electron spin (S = 1) can be polarized and read out optically in a fluorescence microscope. This optically-detected magnetic resonance (ODMR) effect is so sensitive that a single defect can be recorded at ambient temperature and pressure.
We will discuss the potential, recent achievements and...
Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease, which is considered a neglected disease. Medication for this disease is based on empirically discovered drugs with low efficacy, difficulties in administration and severe side effects. The development of a safe and efficient drug is therefore urgently needed.
Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in...
