XXIII Swiss NMR Symposium

Session

NMR session 3

14 Jan 2020, 14:15

503/1-001 - Council Chamber (CERN)

5. Should we care about imperfect pulses?

Matthias Ernst (ETH Zurich)

14/01/2020, 14:15

Pulse sequences in solid-state NMR are usually designed and simulated using the assumption of perfect rectangular or shaped pulses. Since the early 50s it had been recognized that the limited bandwidth of the resonance circuit leads to pulse transients (amplitude and phase) at discontinuities of the phase or amplitude. Therefore, the rotations that the spins experience are not the same as the...

26. Intrinsic magnetic anisotropy of lanthanide chelates and new lanthanide chelating tags for protein NMR spectroscopy

Daniel Häussinger

14/01/2020, 14:30

9. Drug Delivery Systems examined by NMR

Dr Martina Vermathen (University of Bern)

14/01/2020, 14:45

Various polymeric drug delivery systems suitable for physical entrapment of porphyrinic photosensitizers are a focus of our research. In this presentation, it will be shown how NMR can provide useful information on many different aspects such as drug loading and stability of the porphyrin-carrier systems. Classical NMR spectroscopic methods such as NOESY and DOSY are used to analyze drug...

6. Single-spin magnetic resonance using Nitrogen-Vacancy centers in diamond

Takuya Segawa (ETH Zurich)

14/01/2020, 15:00

Nitrogen-Vacancy centers in diamond are fluorescent crystal defects with a unique property: Their electron spin (S = 1) can be polarized and read out optically in a fluorescence microscope. This optically-detected magnetic resonance (ODMR) effect is so sensitive that a single defect can be recorded at ambient temperature and pressure.

We will discuss the potential, recent achievements and...

39. Targeting FPPS by fragment-based lead discovery

Dr Joy Kristin Petrick (Novartis)

14/01/2020, 15:15

Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease, which is considered a neglected disease. Medication for this disease is based on empirically discovered drugs with low efficacy, difficulties in administration and severe side effects. The development of a safe and efficient drug is therefore urgently needed.

Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in...

37. NMR in the web-browser: applications to metabolomics and teaching

Luc Patiny

14/01/2020, 15:30

42. Spin thermometry: deuterium NMR spectra give a straightforward measure of very low spin temperatures resulting from dynamic nuclear polarization

Geoffrey Bodenhausen

14/01/2020, 15:45

Dynamic nuclear polarization of samples at low temperatures, typically between 1.2 and 4.2 K, allows one to achieve spin temperatures as low as 2 mK, so that for many nuclear isotopes the high-temperature approximation is violated. This leads to characteristic asymmetries in powder spectra. We show the lineshapes due to the quadrupolar couplings of deuterium spins that are present in virtually...