August 30, 2021 to September 3, 2021
University of Innsbruck
Europe/Zurich timezone

【135】Quantum Cascade Lab-on-a-Chip for Protein Sensing

Sep 1, 2021, 6:00 PM
Room A

Room A

Talk Condensed Matter Physics (KOND) Condensed Matter Physics


Florian Pilat (TU Wien)


With recent advances in quantum cascade (QC) lasers and detectors the mid-IR spectral region - often called fingerprint region, due to the characteristic fundamental absorption features of molecules in this range – becomes more and more accessible for various spectroscopic applications. Here, we present a compact liquid sensor featuring QC lasers and detectors coupled by plasmonic waveguides on a single semiconductor chip for absorption spectroscopy in the range of 1550$\,$-$\,$1650$\,$cm$^{-1}$. In a proof-of-concept experiment we show its capability of measuring the thermally induced denaturation process, i.e. the change in secondary structure, of the protein bovine serum albumin (BSA) dissolved in D$_2$O in real-time.

Primary author

Florian Pilat (TU Wien)


Laurin Lux (Institute of Chemical Technologies and Analytics, TU Wien) Patricia Lustoza Souza (LabSem-CETUC, Pontifícia Universidade Católica do Rio de Janeiro) Andreas Schwaighofer (Institute of Chemical Technologies and Analytics, TU Wien) Benedikt Schwarz (Institute of Solid State Electronics, TU Wien) Hermann Detz (Institute of Solid State Electronics E362, TU Wien) Aaron Maxwell Andrews (Institute of Solid State Electronics E362, TU Wien) Bernhard Lendl (TU Wien) Gottfried Strasser (TU Wien) Borislav Hinkov (TU Wien)

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