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Fixed target experiments in particle physics provide the possibility of reaching a large number of particle collisions, allowing precise measurements of physics observables. CERN hosts a variety of fixed target experiments that aim at high-precision measurements, few of them located in the so-called North Area. These experiments make use of the 400 GeV/c proton beam coming from the SPS that is led to collide on a target head to produce diverse particle species. Among these experiments there is NA62 that aims at measuring ultra-rare decays (mainly K+ => pi+ nu nu) to a very high precision (10% for K+ => pi+ nu nu) in order to challenge the Standard Model and conduct searches for new particles. In the case of NA62, the P42 beam line transports the 400 GeV/c protons on the T10 target that produces the secondary beam afterwards transported by the K12 beam line to the NA62 detector. Besides NA62, more high-intensity experiments are currently being considered to take place in the P42 and K12 beam line in future. These are: KLEVER, NA62-HIGH-INTENSITY, NA62-BEAM-DUMP and SHADOWS. The nature of these experiments is quite diverse and they all cover different physics topics, including Standard Model investigation and dark matter searches. The studies presented in this seminar examine the beam and background characterization for the beam lines of NA62 and NA62-BEAM-DUMP and SHADOWS together with novel solutions for radiation and intensity challenges for KLEVER and NA62-HIGH-INTENSITY. These studies are carried out mainly using the AppLE.py, BDSIM, MADX and FLUKA software.