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The dose delivered to tissues induces a specific biological effect (i.e. normal tissue sparing associated with sustained tumor control) when ultra-high dose rates (UHDR; > ~40 Gy/s in average) are used. That effect is called the FLASH effect.
Biological experiments were performed on prototype or experimental devices where specific dosimetric procedures had to be developed and validated to reach a reasonable accuracy, because, as an example, no metrological traceability is established for such UHDR beams. Alongside the challenging work to provide adequate beams and correct dose data reporting for pre-clinical experiments, further developments are necessary to produce a large homogeneous beam compatible with clinical requirements. Moreover, an important prerequisite for the use of UHDR for clinical treatments is obviously the safety and reliability of UHDR devices.
I will present the characteristics of available devices as well as potential future machines for the clinical transfer, particularly for deep seated tumors, and describe the challenges that we will face for the safe transfer of that promising technique to patients.
Short bio:
Raphaël Moeckli completed his MSc degree in Ecole Polytechnique Fédérale de Lausanne and his PhD in medical imaging at the University of Lausanne in 2001. He is certified Swiss medical physicists since 1999, head of the radiation therapy group in Institute of Radiation Physics and head physicist in the Radio-Oncology Department in CHUV Lausanne since 2001.
He is associate professor in Lausanne University since 2021. His main fields of research are FLASH therapy, tomotherapy and multicriteria optimisation. He is and has been director and experts for various national and international PhD thesis juries. He has published more than 80 papers in peer-reviewed journal.
He is past president of the Swiss Society of Radiobiology and Medical Physics and he has been active in different working groups having issued Swiss recommendations about good practice in radiation therapy. He has been member of different scientific committees of ESTRO meetings as well as other Swiss and international meetings.
Manuela Cirilli / Participants 80