The 12th international symposium on “Large TPCs for low-energy rare event detection” will be held in Paris on the 15th-17th of December 2025. The purpose of the meeting is an extensive discussion of present and future projects using a large TPC for low-energy, low-background detection of rare events (low-energy neutrinos, double beta decay, dark matter, solar axions). There is an increasing number of experiments using or planning to use very large gaseous or liquid TPCs. A common feature of the detection scheme will be the measurement of the energy and direction of ion recoils. The search for light dark matter is a new challenge calling for low-energy threshold and light recoiling atoms. New ideas are emerging for detector concepts adapted to physics requirements. The use of gaseous micro-pattern detectors seems to be a promising way to reach this goal. The symposium will be held at Amphitheatre Vulpian, at Université Paris Cité, 12 rue de l'Ecole de Médecine, in the Latin Quarter of Paris. This is very close to Notre Dame de Paris, recently rebuilt after the fire which partially destroyed it in 2019. The physics and the present status of dark matter search, axion search, and neutrino studies will be reviewed together with discussions on evolving technologies relevant to these searches.
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