Name: ICTR-PHE 2014
Start: 2014-02-10T12:00:00+01:00
End: 2014-02-14T16:30:00+01:00
Location: Centre International de Conferences de Geneve (CICG)

ICTR-PHE 2014

from Monday 10 February 2014 (12:00) to Friday 14 February 2014 (16:30)

Monday 10 February 2014

12:00 Lunch
Lunch
12:00 - 13:00
13:00 Welcome addresses - Rolf Heuer Manjit Dosanjh Representative of the Geneva state Jacques Bernier
Welcome addresses
- Rolf Heuer
- Manjit Dosanjh
- Representative of the Geneva state
- Jacques Bernier
13:00 - 13:30
13:30
13:30 - 14:00
Contributions

13:30 The Higgs boson and our life - Fabiola Gianotti
14:00
14:00 - 16:00
Contributions

14:00 Ion Beam Radiobiology: From the Lab to the Clinic - Eleanor Blakely

14:30 International Cancer Expert Corps (ICEC) - Norman Coleman

15:00 New challenges for biologically adapted ion beam treatment planning: single and multi-ion approaches - Emanuele Scifoni

15:15 RBE and DNA damage variation along monoenergetic and modulated Bragg peaks of a 62 MeV therapeutic protons beam - Kevin Prise

15:30 Influences of aberrant mitochondrial DNA in cancer and cancer therapy - Marike van Gisbergen

15:45 Hpv Status and Effect on Radiosensitivity in Head and Neck Cancer Tumor Xenografts - Brita S Sørensen
16:00 Coffee
Coffee
16:00 - 16:30
16:30 Radiobiology
Radiobiology
16:30 - 17:00
Contributions

16:30 Rectal cancer and fractionation sensitivity in the neo-adjuvant radiation therapy setting: a project of meta-analysis and radiobiological modeling from individual patient data in randomized and observational data-sets - Raymond Miralbell

16:45 A Biomedical Research Facility at CERN based on the Low Energy Ion Ring - Adriano Garonna
17:00 Nuclear Medicine
Nuclear Medicine
17:00 - 18:15
Contributions

17:00 Radiochemical aspects of radionuclide therapies - Helmut Maecke

17:30 ²¹²Pb-labeled mAbs targeting CEA or HER2 during α-RIT of small peritoneal carcinomatosis – Dose effect relationship? - Jean-Pierre Pouget

17:45 152/161Tb-DOTA-RM6 biodistribution studies in prostate cancer bearing SCID mice and 149Tb sources from CERN-MEDICIS - Thierry Stora

18:00 A radionuclide generator of Erbium-165, an isotope for Auger Therapy - Gregory Severin
Tuesday 11 February 2014
08:30
08:30 - 10:00
Contributions

08:30 Clinical experience with radionuclide therapies - Irene Virgolini

09:00 From bench to bedside: development and early clinical results of 188Re-SSS/Lipiodol for HCC treatment - Nicolas Lepareur

09:15 PIP: a compact recirculating accelerator for the production of medical isotopes - Adina Toader

09:30 Gamma Probe Based on Scintillation Crystal and Silicon Photomultiplier - Konstantin Zhukov

09:45 Preclinical studies and radiopharmaceutical developments with 64Cu produced by ARRONAX facility - Mickael Bourgeois
10:00 Coffee Break
Coffee Break
10:00 - 10:30
10:30
10:30 - 12:30
Contributions

10:30 From CERN to PET/MR - David Townsend

11:00 Software challenges and opportunities for multidisciplinary PET/CT and PET/MR imaging - Dimitris Visvikis

11:30 Prompt gamma imaging of proton pencil beams at clinical beam current - Julien Smeets

11:45 Prediction of β+-activity distributions from PT-PET by means of a yield approach - Stephan Helmbrecht

12:00 ProXY – High performance monolithic pixel tracker for proton tomography - Piero Giubilato

12:15 The recent developments of the FLUKA Monte Carlo code oriented to its applications in Hadrontherapy - Paola Sala
12:30 Lunch
Lunch
12:30 - 13:30
13:30 Detectors & Imaging
Detectors & Imaging
13:30 - 14:15
Contributions

13:30 Different detector concepts for several imaging scenarios: from hadrontherapy monitoring to clinical imaging - Paola Solevi

13:45 An integrated monitoring system for the on-line assessment of particle therapy treatment accuracy - Vincenzo Patera

14:00 Development of Advanced Quality Assurance Instrumentation for Hadrontherapy - David Watts
14:15 New Technologies
New Technologies
14:15 - 15:45
Contributions

14:15 Novel detectors for range assessment in particle therapy - Peter Thirolf

14:45 The ELIMED (Multidisciplinary and Medical applications at the ELI-Beams) network perspectives for laser driven beam applications - Andrea Attili

15:00 Harnessing laser-plasma accelerated ion beams for applications using Gabor lenses - Christopher Hughes

15:15 Positron emission tomography (PET) isotope production from laser-driven proton - John Wong Kai Ding

15:30 A novel TOF-PET detector based on organic scintillators - Pawel Moskal
15:45 Coffee Break
Coffee Break
15:45 - 16:15
16:15 New Technologies
New Technologies
16:15 - 17:30
Contributions

16:15 Requirements from Oncology to Imaging Technologies - Heinz-Peter Schlemmer

16:45 Potential of Detection of fast Cherenkov Photons for Improved Time of Flight Positron Emission Tomography - Stefan Brunner

17:00 Experimental characterization of acoustic detection and imaging for Bragg peak localization in proton therapy - Katia Parodi

17:15 A new elastic image fusion model for lung deformation simulation in 4D dose calculations - Stefan Milz
18:30 Physics is beautiful and useful - Ugo Amaldi (TERA Foundation (IT))
Physics is beautiful and useful
- Ugo Amaldi (TERA Foundation (IT))
18:30 - 19:30
Room: 2
20:00 Cocktail
Cocktail
20:00 - 20:45
Wednesday 12 February 2014
08:30
08:30 - 09:00
Contributions

08:30 Individualized Radiation Oncology – harnessing clinics, biology and high technology - Michael Baumann
09:00
09:00 - 10:00
Contributions

09:00 Health implications and applications in space - Christer Fuglesang

09:30 The convergence of science - the way to develop novel radiation oncology technologies for the future - Dag Rune Olsen
10:00 Coffee Break
Coffee Break
10:00 - 10:30
10:30
10:30 - 12:00
Contributions

10:30 Current status of Carbon Ion Radiotherapy at NIRS - Hirohiko Tsujii

11:00 Radioisotopes - the "fuel" for nuclear medicine - Ulli Koster

11:30 Medical applications at CERN - Steve Myers
12:00 Lunch
Lunch
12:00 - 13:00
13:00
13:00 - 14:15
Contributions

13:00 New insights into the complexities of NHEJ and HR repair - Simon Powell

13:25 Homologous recombination deficiency and radio-curability in mouse models for BRCA1/2-deficient breast cancer - Sven Rottenberg

13:50 Mechanism of HR dysfunction in single dose radiotherapy - Zvi Fuks
13:00 - 14:15
Contributions

13:00 New insights in IGRT for prostate cancer - Marcel Van Herk

13:25 Adaptive radiotherapy - Vincent Gregoire

13:50 New health technologies and evidence-based medicine - Soren Bentzen
14:15 Coffee Break
Coffee Break
14:15 - 14:45
14:45
14:45 - 16:25
Contributions

14:45 Carbon Ion Therapy: Actual and Future Strategies at HIT - Jurgen Debus

15:10 Present status of CNAO - Roberto Orecchia

15:35 Proton Radiation Therapy: Current Status of Clinical Trials - Thomas Delaney

16:00 France HADRON: national infrastructure for hadrontherapy research including ETOILE, ARCHADE and protontherapy centers - Jacques Balosso
14:45 - 16:25
Contributions

14:45 The development of a low energy facility for clinical trials of Boron Neutron Capture Therapy - Rob Edgecock

14:55 Interstitial Detectors for Synchronized Radiation Quality - Giulio Magrin

15:05 An innovative on-line beam-monitoring detector based on the emission of secondary electrons - Saverio Braccini

15:15 Radiotherapy Dose Monitoring to Low-Dose Morphologic Imaging with Scanned Megavoltage X-rays - Paulo Crespo

15:25 Data models for the Compton camera acquisition and their influence on the reconstructed images - Voichita Maxim

15:35 Detection of ionizing radiation by intrinsic optical fiber sensors: preliminary results - Laura Cella

15:45 First investigations of Ultra-Thin 3D silicon detectors as microdosimeters - Celeste Fleta

15:55 Frequency difference electrical impedance tomography for imaging lung tumour - Chuan Li Yang

16:05 A novel dual-modality optical tomography and x-ray system for small animal radiation research platform - Ken Kang Hsin Wang

16:15 Digital Image Processing Techniques for Application in a Microbeam End-Station Microscopy - Antonios Georgantzoglou
16:30
16:30 - 18:00
Contributions

16:30 DCE-MRI and DCE-US quantification in CWR22 prostate tumour xenografts - Natalia Arteaga-Marrero

16:40 Antitumor activity of combination therapy with TH-302 and irradiation in a rat rhabdomyosarcoma model - Sarah Peeters

16:50 Development of a novel ELISA for detecting inducible Hsp70 in serum - Stephanie Ertl

17:00 Advancing the small animal radiation research platform for pre-clinical radiation research - John Wong

17:10 Evaluation of Late Toxicity Risk for RT Patients through Geant 4 Simulation of X-Ray Dose Deposition - Frederic Brochu

17:20 Log file based dose calculations as a quality assurance tool in scanned beam proton radiotherapy - Gabriel Meier

17:30 A Novel Radioguided Surgery Technique Exploiting - decays - Riccardo Faccini

17:40 Investigation of irregular motion influence for future 4D In-beam PET imaging - Yuan Tian

17:50 Ongoing investigations on ion-based radiography and tomography - Lorena Magallanes
16:30 - 18:10
Contributions

16:30 Initial Qualification of the Irradiation Uncertainties in Ion Beam Therapy of Prostate Cancer - Antoni Rucinski

16:40 Can particle beam therapy be improved using helium ions? - A treatment planning study focusing on pediatric patients - Barbara Knaeusl

16:50 MCTP: a new Monte Carlo-based treatment planning tool for hadrontherapy - Giusseppe Battistoni

17:00 PlanIt: Planning Ion therapy open platform for treatment plans testing and comparing - Faiza Bourhaleb

17:10 Robustness of range prediction in proton therapy using prompt gamma emission - Fiere Janssen

17:20 Simulation of Hadrontherapy In-beam monitoring at CNAO with the INSIDE detector - Piergiorgio Cerello

17:30 Evaluation of existing ripple filter designs for clinical use at the MedAustron ion beam therapy facility - Loic Grevillot

17:40 The (non-) detectability of failures in motion mitigated ion beam delivery by means of in-beam PET - Kristin Stützer

17:50 Assessment and improvements of Geant4 models in the context of prompt-gamma hadrontherapy monitoring - George Dedes

18:00 Monte Carlo modelling of whole-body secondary cancer risk for conventional and emergent radiotherapy - Richard Hugtenburg
19:00 Gala Dinner
Gala Dinner
19:00 - 22:00
Thursday 13 February 2014
08:15
08:15 - 08:50
Contributions

08:15 Host and Tumor Immunity: Local and Systemic Opportunities to Enhance Tumor Curability by Radiotherapy - Ralph Weichselbaum
08:50
08:50 - 10:05
Contributions

08:50 Identification of new therapeutic targets - Conchita Vens

09:15 Single-dose radiotherapy: from learning curve to long-term clinical outcome - Carlo Greco

09:40 From bench to bedside: experience of the glioblastoma model for the optimization of radiosensitization - Elizabeth Moyal
08:50 - 10:05
Contributions

08:50 Hypoxia-induced gene expression - Marianne Koritzinsky

09:15 Impact of tumor autophagy on solid tumors response to IR: role of the tumor stroma - Eric Deutsch

09:40 Hypoxia: where to go from here? - Jens Overgaard
10:05 Coffee Break
Coffee Break
10:05 - 10:30
10:30
10:30 - 11:50
Contributions

10:30 The new business model of the EORTC - Emad Shash

10:50 The Radiation Oncology Group of the EORTC: from the past to the future - Philippe Maingon

11:10 The new drug and radiotherapy working party - Conchita Vens

11:30 An example of the integrated model: the EORTC DAHANCA-1219 trial - Vincent Gregoire
10:30 - 11:50
Contributions

10:30 Enhanced RBE of sub-micrometer focused low-LET protons - Thomas Schmid

10:40 Expression of common or species specific DNA damage-repair pathway related genes in thymus of low-dose-rate irradiated AKR/J and ICR mice - Hee Sun Kim

10:50 [18F] HX4 PET imaging of tumour hypoxia in HNSCC patients - Karen Zegers

11:00 Inhibition of tumour growth using the small molecule Cathepsin L inhibitor, KGP94 - Thomas Wittenborn

11:10 Delayed and Persistent Response of Human Mitochondria after Single Exposure to 0.5 to 4 Gy of Gamma Radiation - Winnie Kam

11:20 Dosimetric considerations to determine the optimal technique for localized prostate cancer - Peter Kuess

11:30 Auger electron emitters labeled to monoclonal antibodies trigger cell membrane-mediated bystander effects - Jean-Pierre Pouget

11:40 Comparing Ion Computed Tomography under clinical constraints - David Hansen
10:30 - 11:50
Contributions

10:30 Ultimate Time Resolution in Time-of-Flight PET - Paul Lecoq

10:40 Ultrafast PET Detectors Based on Digital SiPMs and Their Use in In-Situ PET and Prompt Gamma Ray Imaging - Dennis Schaart

10:50 4D Dose calculations and 4D PET image reconstruction using deformable tetrahedral models of moving organs - Petre Manescu

11:00 Motion compensated reconstructions in PET-based ion beam treatment verification for moving target - Chiara Gianoli

11:10 Usage of long axial crystals for PET applications: the AX-PET demonstrator and beyond - Chiara Casella

11:20 Realistic on-the-fly dose calculation for low energy X-rays Intra-Operative Radiation Therapy - Marie Vidal

11:30 A single device for mechanical and radiation Quality Assurance measurements of medical accelerators - Ernesto Valverde John Wong

11:40 A combined electrical impedance tomography and cone beam CT for radiation therapy monitoring - Manuchehr Soleimani
11:50
11:50 - 12:30
Contributions

11:50 Oxygen ions achieve better tumour control probability in hypoxic tumours than carbon ions do - Niels Bassler

12:00 Direct evaluation of ion beam radiobiological parameters from clinical data: an alternative approach to the RBE - Andrea Attili

12:10 Equivalent uniform dose (EUD) based biological optimization for carbon ion therapy - Sarah Brüningk

12:20 Variance Based Sensitivity Analysis of Biological Uncertainties in Carbon Ion Therapy - Florian Kamp
11:50 - 12:30
Contributions

11:50 TOF-PET scanner configurations for quality assurance in proton therapy: a patient case study - Peter Dendooven

12:00 Implementation of a GPU Monte Carlo protons transport code for dose calculations: methods and challenges - Daniel Maneval

12:10 Fast pencil beam dose calculation for hadron therapy on GPU - Joakim Da Silva

12:20 Parameterization of lateral dose profiles for proton therapy application at CNAO - Martina Mori
11:50 - 12:30
Contributions

11:50 Modelling acute urinary toxicity after radiotherapy for prostate cancer - Tiziana Rancati Viviana Caillo

12:00 Mediators associated to the inflammatory response in prostate cancer patients undergoing RT: preliminary results - Bedini Nice

12:10 Daily variation in rectal size and position during prostate radiotherapy measured from helical tomotherapy CT scans - Jessica Scaife

12:20 Clinical experience with adaptive radiotherapy for muscle invasive bladder cancer - Anne Vestergaard
12:30 Lunch
Lunch
12:30 - 13:30
13:30
13:30 - 14:00
Contributions

13:30 The ART of translation - Marcel Verheij
14:00
14:00 - 15:15
Contributions

14:00 Eulogy of Professor Kian K. Ang - James Cox

14:25 Milestones of Pr Kian Ang’s scientific contribution - Jacques Bernier

14:50 Molecular biology of head and neck carcinomas: old challenges, new insights - Kevin Harrington
15:15 Coffee Break
Coffee Break
15:15 - 15:45
15:45
15:45 - 16:35
Contributions

15:45 Vimentin (EMT Marker Protein) Score As One of Predictors Resistance to Erlotinib and Radiotherapy for Patients with Stage III Non-Small Cell Lung Cancer on A Prospective Phase II Trial - Ritsuko Komaki

15:55 Towards simpler and better prediction of relative biological effect (RBE) - Bleddyn Jones

16:05 Combined Radiochemotherapeutical Strategies for Microtubule Stabilizing Agent (MSA)-Resistant Tumors - Angela Broggini-Tenzer

16:15 Preclinical Assessment of Efficacy of Radiation Dose Redistribution Based on Intratumoral FDG-PET Uptake - Ludwig Dubois

16:25 Fat percentage and hand grip strength in lung cancer: the influence on survival and toxicity - Kim Smits
15:45 - 16:35
Contributions

15:45 Verification of dynamictrajectory radiotherapy based on Monte Carlo - Michael Fix

15:55 Development of a transparent photon detector for the online monitoring of IMRT beams - Rachel Delorme

16:05 An Intensity Modulated Radiotherapy Beam Monitoring System using a Monolithic Active Pixel Sensor - Johannes Velthuis

16:15 Geant4 simulation of a dedicated beam line at the CNAO facility for the study of uveal melanomas - Edoardo Farina

16:25 EndoTOFPET-US: A multimodal ultrasound and time of flight PET endoscope for developing new biomarkers for the prostate and pancreatic cancers - Etiennette Auffray
15:45 - 16:35
Contributions

15:45 The REQUITE project: validating predictive models and biomarkers of radiotherapy toxicity to reduce side-effects - Tiziana Rancati

15:55 Potentiation of radiation response by a novel EGFR/DNA targeting molecule in a triple negative breast cancer model - Beatrice Fournier

16:05 Studying inter- and intrafraction motion mitigation with sequential 4D CTs of lung tumor patients - Romain Brevet

16:15 Time resolved portal dosimetry for Volumetric Modulated Arc Therapy (VMAT) in lung cancer patients with atelectasis - Mark Podesta

16:25 Spot-scanning Proton Therapy for Pediatric Parameningeal Rhabdomyosarcomas: Clinical Outcome of 39 Patients Treated at PSI - Carmen Ares
16:45 CERN visit
CERN visit
16:45 - 19:00
Room: ATLAS

19:00 Cocktail in Globe
Cocktail in Globe
19:00 - 20:00
Room: Globe of Science and Innovation
Friday 14 February 2014
08:30
08:30 - 09:45
Contributions

08:30 Panel discussion - Hirohiko Tsujii James Cox Jürgen Debus Roberto Orecchia
08:30 - 09:45
Contributions

08:30 Growth factor and integrin receptor targeting - there is more to it than just inhibition - Nils Cordes

08:55 Notch and radiotherapy: does it matter? - Marc Vooijs

09:20 Head-and-neck cancers: towards new, intriguing fractionation schedules - Jean Bourhis
09:45 Coffee Break
Coffee Break
09:45 - 10:15
10:15
10:15 - 11:45
Contributions

10:15 Radiosensitization of Non–Small Cell Lung Cancers by Targeting Ionizing Radiation-Induced Activation of ADAM17 - Martin Pruschy

10:30 Do physiological relevant doses of biguanides have any role in cancer treatment? - Morten Busk

10:45 Oral mucosal radiation response (mouse) - relevance of ceramide-induced apoptosis? - Wolfgang Dörr

11:00 A phase I/II study of proton and hyperthermia in primary unresectable and recurrent adult soft tissue sarcoma - Niloy Datta
10:15 - 11:35
Contributions

10:15 Radiobiological Considerations for Retreatment of Central Nervous System Tumours - Bleddyn Jones

10:25 Gadolinium based nanoparticles for radiosensitization of head and neck squamous cell carcinoma - Lucie Sancey

10:35 Noninvasive Imaging of Radiation-Induced Lung Inflammation with Positron Emission Tomography (PET) in a Murine Model - Jin Zhang Ken Kang Hsin Wang

10:45 The use of ‘planned overshoot’ for reducing dose to healthy tissue and improve treatments robustness for scanned proton beams - Francesca Albertini

10:55 Clinical testing of an in-room imaging system for patient setup verification in particle therapy - Guido Baroni

11:05 Reduced side effects by proton microchannel radiotherapy – study in a human skin model - Stefanie Girst

11:15 Entervision Wp4. Biological Dosimetric Phantom. Proof Of Concept Preliminary Results - Thiago Viana Miranda Lima

11:25 A knowledge exchange case study: computational radiotherapy at Cambridge - Michael Simmons
10:15 - 11:45
Contributions

10:15 Intra-fraction tumor tracking based on a surrogate-driven 4D CT motion model in particle radiation therapy - Guido Baroni

10:25 Prompt Gamma Imaging at MGH with LaBr3 Scintillating Crystals - Joao Seco

10:35 Nanoparticles and protontherapy: disentangling possible physical effects - Yolanda Prezado

10:45 95 MeV/A carbon fragmentation studies for hadrontherapy: measurements and comparisons with GEANT4 simulations - Marc Labalme

10:55 Properties of therapeutic He, Li and O beams studied with Geant4 - Lucas Burigo

11:05 Automatic beam dose profiler for scanned pencil beams (protons and carbon ions) at the CNAO hadrontherapy facility - Aurora Tamborini

11:15 Proton Interaction Vertex Imaging for carbon therapy quality control - Regina Rescigno

11:25 Dual energy CT to reduce range uncertainties in hadrontherapy - Guillaume Landry

11:35 Research and development of a TOF-based multi-slit collimated camera for online hadrontherapy monitoring - Marco Pinto
11:45 Lunch
Lunch
11:45 - 12:45
12:45
12:45 - 14:00
Contributions

12:45 Evolution of technology to optimize the delivery of proton therapy: the third generation - Thomas Bortfeld

13:10 Robust optimization of IMPT dose distributions - Radhe Mohan

13:35 Proton clinical correlates of patient throughput and cyclotron availability - Kevin McMullen
12:45 - 14:00
Contributions

12:45 Hypoxia Imaging - Marianne Nordsmark

13:10 Functional image-based target definition - Robert Jeraj

13:35 Predictive and prognostic role of functional imaging of head and neck squamous cell carcinomas - David Brizel
12:45 - 14:00
Contributions

12:45 Hypoxia modification in experimental tumours - Daniel Zips

13:10 The vascular supply and microenvironment of tumours and their significance for cancer therapy - Michael Horsman

13:35 Targeting hypoxia through autophagy - Kasper Rouschop
14:00
14:00 - 15:15
Contributions

14:00 Biomarker for stratification in radiotherapy - preclinical and early clinical models - Mechthild Krause

14:25 Imaging for prescription function - Daniela Thorwarth

14:50 How will we develop the evidence base for biologically individualized radiotherapy? - Tim Maughan
14:00 - 15:20
Contributions

14:00 Carbonic Anhydrase IX inhibitors: a new class of targeted agents - Philippe Lambin

14:20 Immunosensitization by radiotherapy: the example of immunocytokines - Ludwig Dubois

14:40 Novel strategies to spare normal tissues from radiation damage - Marie-Catherine Vozenin

15:00 Intestinal Stem Cells are Radiation Resistant - Richard Kolesnick
15:20 Concluding remarks - Manjit Dosanjh (CERN) Jacques Bernier
Concluding remarks
- Manjit Dosanjh (CERN)
- Jacques Bernier
15:20 - 15:40

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